Transmission electron microscopy of the cochlear organ of Corti in experimental endolymphatic hydrops revealed two principal features. Starting 1 month after induction of hydrops, osmiophilic inclusions thought to represent lipofuscin accumulation were frequently observed in the subcuticular cytoplasm of the outer hair cells along the length of the cochlea. Starting 3 months after induction of hydrops the efferent terminals on the outer hair cells appeared to be vacuolated. These data suggest that oxidative insult is likely to contribute to the pathology associated with endolymphatic hydrops and thus that free radical scavengers might be useful in the treatment of Menière's disease patients. In addition the early modification of the efferent innervation of the hydropic cochlea might underlie the known hypersensitivity to various insults, including noise stimulation, glycerol administration and hypoxia.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1111/j.1460-9568.1995.tb01121.x | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Circadian rhythm disruptions exacerbate inner ear damage in a murine endolymphatic hydrops model.
FASEB J
January 2025
Department of Otolaryngology-Head and Neck Surgery, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Meniere's disease (MD) is an inner ear disease characterized by endolymphatic hydrops (EH). Maintaining a regular daily routine is crucial for MD patients. However, the relationship between circadian rhythms and MD remains unclear.
View Article and Find Full Text PDFIs endolymphatic hydrops, as detected in MRI, a truly cochleocentric finding?
Front Neurol
December 2024
Department of Radiology, Clínica Universidad de Navarra, Madrid, Spain.
Introduction: The most common histopathological finding in Ménière's disease (MD) is endolymphatic hydrops (EH), which involves the dilation of the membranous labyrinth. The direct relationship between EH and MD is debated, although EH plays a crucial role in auditory and vestibular functional tests. MRI sequences such as 3D-FLAIR and 3D-real-IR are used to study EH, with the latter being more effective.
View Article and Find Full Text PDFMeniere's disease: Structural considerations in early cochlea hydrops.
Laryngoscope Investig Otolaryngol
December 2024
Department of Otolaryngology Columbia University New York New York USA.
Article Synopsis
- The human cochlea's unique structure may influence the formation of lesions in endolymphatic hydrops, focusing on its flattened spiral shape, the toroidal structure of the cochlear duct, and the flexibility of Reissner's membrane.
- An analytical approach using a normal cochlea's dimensions was developed to evaluate variations in distention across the cochlea's turns, with stresses and strains calculated for Reissner's membrane.
- Results indicated that stress in Reissner's membrane increases from the basal to the apical turn, with higher strain and displacement observed at the apex, suggesting that the cochlea's structural features play a critical role in its vulnerability to hydrops.
Hearing loss and vestibular dysfunction in congenital CMV infection: Could it be due to endolymphatic pressure anomaly? A preliminary study.
Int J Pediatr Otorhinolaryngol
November 2024
Department of Paediatric Otolaryngology, Robert Debre Hospital, Assistance Publique Hôpitaux de Paris (APHP), Paris Cité University, Paris, France; Center for Balance Evaluation in Children (EFEE), Department of Paediatric Otolaryngology, Robert Debre Hospital, Assistance Publique Hôpitaux de Paris (APHP), Paris Cité University, Paris, France.
Objectives: To describe the inner ear sectors after an inner ear MRI protocol and search for the presence of endolymphatic pressure anomaly in patients presenting with a congenital CMV infection and audio-vestibular dysfunction.
Methods: A 3D FLAIR MRI sequence, 4 h after gadolinium injection, was performed in patients with sensory-neural hearing loss secondary to a congenital CMV infection in order to analyse the morphology of the endolymphatic space.
Results: Two patients presented with a unilateral SNHL and 4 patients a bilateral SNHL.
The diagnostic performance of cochlear endolymphatic hydrops and perilymphatic enhancement in stratifying Ménière's disease probabilities: A meta-analysis of semi-quantitative MRI-based grading systems.
PLoS One
November 2024
Department of Otorhinolaryngology-Head and Neck Surgery, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran.
Background: The diagnosis of Meniere's Disease (MD) presents significant challenges due to its complex symptomatology and the absence of definitive biomarkers. Advancements in MRI technology have spotlighted endolymphatic hydrops (EH) as a key pathological marker, necessitating a reevaluation of its diagnostic utility amidst the need for standardized and validated MRI-based grading scales.
Methods: Our meta-analysis scrutinized the diagnostic efficacy of semi-quantitative MRI-based cochlear endolymphatic hydrops (EH) and perilymphatic enhancement (PLE) grading systems in delineating clinically relevant discriminations: "Spotting" the shift from normal or asymptomatic ears to possible/probable MD (pMD), "Confirming" the progression to definite MD (dMD), and "Establishing" the presence of dMD.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!