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Modelling SARS-CoV-2 infection in a human alveolus microphysiological system.
Access Microbiol
September 2024
Quadram Institute Bioscience, Norwich Research Park, Norwich, NR4 7UQ, UK.
The coronavirus 2019 pandemic has highlighted the importance of physiologically relevant models to assist preclinical research. Here, we describe the adaptation of a human alveolus microphysiological system (MPS) model consisting of primary human alveolar epithelial and lung microvascular endothelial cells to study infection with SARS-CoV-2 at Biosafety Level 3 facility. This infection model recapitulates breathing-like stretch and culture of epithelial cells at the air-liquid interface and resulted in clinically relevant cytopathic effects including cell rounding of alveolar type 2 cells and disruption of the tight junction protein occludin.
View Article and Find Full Text PDFMetastatic Malignant Granular Cell Tumor in the Lymph Node: A Cytological Report With Immunocytochemical Analysis.
Diagn Cytopathol
December 2024
Department of Pathology and Division of Diagnostic Pathology, Osaka Medical and Pharmaceutical University, Osaka, Japan.
Granular cell tumors (GCTs) are relatively rare, whereas malignant GCTs are extremely rare. This brief report describes a cytological case of metastatic malignant GCT in the lymph node with immunocytochemical analysis. A 77 years old Japanese female with a history of surgical resection for malignant GCT in the back 8 years earlier presented with swelling of the right neck.
View Article and Find Full Text PDFThe Potential of a Novel Cold Atmospheric Plasma Jet as a Feasible Therapeutic Strategy for Gingivitis-A Cell-Based Study.
Cells
November 2024
Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Bucharest, 91-95 Spl. Independentei, 050657 Bucharest, Romania.
Due to its antimicrobial, anti-inflammatory and pro-healing properties, the application of cold atmospheric plasma (CAP) has emerged as a new and promising therapeutic strategy in various fields of medicine, including general medicine and dentistry. In this light, the aim of the present study was to investigate the effects of a homemade plasma jet on the cellular behaviour of two important cell types involved in gingivitis, namely gingival fibroblasts (HGF-1 cell line) and macrophages (RAW 264.7 cell line), by the direct application of CAP in different experimental conditions.
View Article and Find Full Text PDFBilateral Cystic Endosalpingiosis in Cervical Lymph Nodes Mimicking Metastatic Papillary Thyroid Carcinoma Morphologically on Cytology: A Case Report and Literature Review of Diagnostic Challenges.
Diagn Cytopathol
December 2024
Division of Pathology and Laboratory Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
The presence of cystic lymph nodes in the neck can present a challenging differential diagnosis, with considerations often including metastatic papillary thyroid carcinoma (PTC), cystic squamous cell carcinoma, and congenital cysts. The cytologic overlap between benign Müllerian inclusions and PTC features adds complexity, especially in unusual locations. A 45-year-old woman with a history of ovarian serous borderline tumor (SBT) and non-invasive Müllerian implants presented with cystic lymphadenopathy in the neck.
View Article and Find Full Text PDFComparative analysis of the effects of different hypoxia mimetic agents on the secretome contents of conditioned medium obtained from mesenchymal stem/stromal cells cultured in 2 or 3-dimensional cell culture systems.
Cytotechnology
February 2025
Cerrahpaşa Faculty of Medicine, Histology and Embryology Department, Istanbul University-Cerrahpaşa, Istanbul, Turkey.
Paracrine factors secreted by mesenchymal stem/stromal cells (MSCs) have been demonstrated to have significant therapeutic potential. The secretome profiles of MSCs variate depending on culture conditions. Generally, the effects of a single preconditioning strategy on secretome profiles of MSCs were investigated.
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