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Oral Delivery of miR146a Conjugated to Cerium Oxide Nanoparticles Improves an Established T Cell-Mediated Experimental Colitis in Mice.
Pharmaceutics
December 2024
Laboratory for Fetal and Regenerative Biology, Department of Surgery, University of Arizona Tucson College of Medicine, Banner Children's at Diamond Children's Medical Center, 1656 E Mabel St, Rm 230, Tucson, AZ 85721, USA.
Dysregulated inflammation and oxidative stress are strongly implicated in the pathogenesis of inflammatory bowel disease. We have developed a novel therapeutic that targets inflammation and oxidative stress. It is comprised of microRNA-146a (miR146a)-loaded cerium oxide nanoparticles (CNPs) (CNP-miR146a).
View Article and Find Full Text PDFApplying Resin Radial Injection for Manufacturing Fiber-Reinforced Polymer Composite: Advanced Mathematical Modeling and Simulation.
Polymers (Basel)
December 2024
Department of Mechanical Engineering, Federal University of Campina Grande, Campina Grande 58429-900, PB, Brazil.
Recently, the liquid composite molding technique (LCM) has been used for producing fiber-reinforced polymer composites, since it allows the molding of complex parts, presenting good surface finishing and control of the mechanical properties of the product at the end of the process. Studies in this area have been focused on resin transfer molding (RTM), specifically on the resin rectilinear infiltration through the porous preform inserted in the closed cavity neglecting the sorption effect of the polymeric fluid by the reinforcement. Thus, the objective of this work is to predict resin radial flow in porous media (fibrous preform), including the effect of resin sorption by fibers considering a one-dimensional approach.
View Article and Find Full Text PDFMetal Transfer Behavior and Molten Pool Dynamics in Cold Metal Transfer Pulse Advanced Additive Manufacturing of 7075 Aluminum Alloy.
Micromachines (Basel)
December 2024
The Institute of Technological Sciences, Wuhan University, Wuhan 430072, China.
Wire arc additive manufacturing (WAAM) with a special arc mode of cold metal transfer pulse advanced (CMT-PADV) is an ideal additive manufacturing process for fabricating aerospace components, primarily high-strength aluminum alloys, offering advantages such as high deposition rates and low cost. However, the numerical simulation of the CMT-PADV WAAM process has not been researched until now. In this study, we first developed a three-dimensional fluid dynamics model for the CMT-PADV WAAM of 7075 aluminum alloy, aiming at analyzing the droplet transition and molten pool flow.
View Article and Find Full Text PDFTransition Boundary from Laminar to Turbulent Flow of Microencapsulated Phase Change Material Slurry-Experimental Results.
Materials (Basel)
December 2024
Department of Mechanical and Power Engineering, Koszalin University of Technology, Raclawicka Street 15-17, 75-620 Koszalin, Poland.
An ice slurry or an emulsion of a phase change material (PCM) is a multiphase working fluid from the so-called Latent Functional Thermal Fluid (LFTF) group. LFTF is a fluid that uses, in addition to specific heat, the specific enthalpy of the phase change of its components to transfer heat. Another fluid type has joined the LFTF group: a slurry of encapsulated phase change material (PCM).
View Article and Find Full Text PDFParallel Bayesian Optimization of Thermophysical Properties of Low Thermal Conductivity Materials Using the Transient Plane Source Method in the Body-Fitted Coordinate.
Entropy (Basel)
December 2024
New Energy and Environmental Protection Technology Innovation Platform, Suzhou Research Institute of Shandong University, Suzhou 215123, China.
The transient plane source (TPS) method heat transfer model was established. A body-fitted coordinate system is proposed to transform the unstructured grid structure to improve the speed of solving the heat transfer direct problem of the winding probe. A parallel Bayesian optimization algorithm based on a multi-objective hybrid strategy (MHS) is proposed based on an inverse problem.
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