For tocolysis in pregnancy and labour the authors have used Dilatol (Bufenin) since 1970 and Partusisten since 1976. In 1977 tocolysis was applied in 354 pregnant women (10.6%) : 63 (17.8%) were give tocolytics for premature pain, 18 (5.1%) for the premature rupture of the fetal membranes, and 273 (77.1%) for prophylactic reasons, mostly following cerclage and in cases of multiple pregnancy. In the therapeutic use of tocolysis in 63 women, pain disappeared in 46 of them and they continued to be treated in the out-patient unit; 17 women continued being treated with tocolytics until the beginning of premature labour.20
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Article Synopsis
- * The analysis included 15 randomized clinical trials involving 2,186 pregnant women and found that nifedipine was generally more effective than magnesium sulfate, although both drugs similarly prolonged pregnancy by 48 hours in some cases.
- * Magnesium sulfate had more side effects than nifedipine, and further research is needed to confirm these findings through large-scale studies.
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