Treatment with interleukin-12 (IL-12) significantly reduced the number of viable bacteria in mice infected with Mycobacterium avium. IL-12 itself, however, could not inhibit directly mycobacterial growth in vitro. IL-12 exerts antimycobacterial activity in vivo with a low level of toxicity, possibly by enhancing the host defense against the infection.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC162744 | PMC |
| http://dx.doi.org/10.1128/AAC.39.6.1369 | DOI Listing |
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