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Terbinafine in acrylic polymer for the treatment of onychomycosis in hemodialysis patients: a phase II clinical trial.
Front Med (Lausanne)
November 2024
Laboratory of Molecular Biology and Genetics, Health Sciences Postgraduate Program, São Francisco University, Bragança Paulista, Brazil.
Introduction: Onychomycosis is a nail infection caused by dermatophyte fungi, non-dermatophyte fungi, and yeast. Patients with chronic kidney disease on dialysis are part of the population that presents higher rates of this disease, mainly due to immunosuppression. Among patients with chronic kidney disease on dialysis, the treatment of onychomycosis is complex, mainly due to the limitations imposed by comorbidities.
View Article and Find Full Text PDFFirst case of pustular eyelid allergic contact dermatitis to methacrylates in artificial nails.
Contact Dermatitis
November 2024
Department of Occupational and Environmental Diseases, Hotel-Dieu Hospital, APHP, Centre-Université Paris Cité, AP-HP, Paris, France.
Is the Use of the Extended (Meth)acrylate Series - Nails Justified? Characterization of Nail Acrylate Allergy in a Tertiary Medical Centre.
Acta Derm Venereol
November 2024
Department of Dermatology, Rambam Health Care Campus, Haifa, Israel; The Ruth and Bruce Rappaport Faculty of Medicine, Technion - Israel Institute of Technology, Haifa, Israel.
Article Synopsis
- Methacrylate allergy, linked to allergic contact dermatitis, has become more prevalent, leading to the addition of 2-hydroxyethyl methacrylate to the European Baseline Series of allergens.
- A study analyzing 3,828 patients showed that 396 were tested for various methacrylate allergens, with 38.6% testing positive for at least one, primarily 2-hydroxyethyl methacrylate.
- The research indicated that including additional methacrylates, like hydroxypropyl methacrylate and ethylene glycol dimethacrylate, improved detection rates significantly, suggesting that broader testing could identify more cases of allergy.
Allergic Contact Dermatitis to Acrylates: A Case Report.
Cureus
August 2024
Dermatology, "Carol Davila" University of Medicine and Pharmacy, Bucharest, ROU.
Article Synopsis
- - Methacrylates, commonly found in medical and aesthetic products, are a leading cause of allergic contact dermatitis (ACD).
- - Extended use of sanitary pads can increase the risk of developing ACD from various allergens.
- - The report discusses a young woman who experienced nail contact dermatitis that escalated into severe ACD in the genital area due to methacrylates in menstrual pads.
Pandemic of sensitivity to acrylate containing nail cosmetic among young Israeli women? Result of patch testing 2-hydroxyethyl methacrylate in the European baseline series.
Contact Dermatitis
December 2024
Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Article Synopsis
- 2-Hydroxyethyl methacrylate (HEMA) was included in the European baseline series in 2019, but there's limited data on how often people are exposed to it, especially in Israel.
- A study of 1,671 patients from 2020 to 2023 found that 8.1% reacted positively to HEMA, with much higher sensitivity in young women (16.7% among those under 30) compared to men (1.0%).
- Most positive reactions were linked to nail cosmetics, and 84% of cases were deemed clinically relevant, suggesting significant occupational exposure, particularly among nail stylists.
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