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Comparing NGS-Based identification of bloodstream infections to traditional culture methods for enhanced ICU care: a comprehensive study.
Front Cell Infect Microbiol
September 2024
Department of Critical Care Medicine, Shenzhen People's Hospital, Second Clinical Medical College of Jinan University, First Affiliated Hospital of Southern University of Science and Technology, Shenzhen, Guangdong, China.
Background: Accurate identification of infectious diseases using molecular techniques, such as PCR and NGS, is well-established. This study aims to assess the utility of Bactfast and Fungifast in diagnosing bloodstream infections in ICU settings, comparing them against traditional culture methods. The objectives include evaluating sensitivity and specificity and identifying a wide range of pathogens, including non-culturable species.
View Article and Find Full Text PDFCeftriaxone-resistant viridans streptococci bacteraemia among patients treated at a large comprehensive cancer care centre: a retrospective eighteen-year study.
JAC Antimicrob Resist
August 2024
Department of Laboratory Medicine and Pathology, University of Washington, 1959 NE Pacific St., Box 357470, Seattle, WA 98195-7470, USA.
Objectives: Viridans streptococci (VS) are opportunistic oral commensals and a common cause of bacteraemia in neutropenic patients. In this retrospective single centre cohort study, we investigated the prevalence of ceftriaxone resistance in VS (CRO-R VS) blood isolates between January 2005 and December 2022 from patients treated at a tertiary care hospital.
Methods: Blood culture isolates were identified using biochemicals and mass spectrometry.
Clinicomicrobiological risk factors for infective endocarditis in viridans group streptococci bacteraemia.
J Antimicrob Chemother
September 2024
Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea.
Article Synopsis
- The study investigates when to use echocardiography to check for infective endocarditis (IE) in patients with bloodstream infections caused by viridans group streptococci (VGS).
- It identifies key risk factors for IE, finding that heart valve disease, persistent bacteria in the blood, younger age, and infections from specific VGS species significantly increase risk.
- The findings suggest that echocardiography should be considered for patients showing these risk factors, to improve diagnosis and management of potential IE cases.
Low rates of complications and β-lactam resistance in viridans group streptococci bloodstream infection among cancer patients receiving chemotherapy.
J Antimicrob Chemother
August 2024
Faculty of Medicine, Centre for Clinical Research, The University of Queensland, Brisbane, Australia.
Background: Viridans group streptococci (VGS) bloodstream infection (BSI) frequently occurs in cancer patients receiving chemotherapy, and is associated with infective endocarditis (IE) in up to 20% of cases in the general population.
Objectives: In cancer patients receiving chemotherapy with VGS BSI, we aimed to: (i) determine the incidence of infective complications including IE, (ii) assess the utility of echocardiography in this patient population, (iii) determine the duration and type of antimicrobial therapy received for monomicrobial infections, and (iv) determine the evolution of antimicrobial resistance.
Methods: VGS BSIs (excluding Streptococcus pneumoniae and Streptococcus pseudopneumoniae) in cancer patients receiving chemotherapy were identified from a statewide public pathology database between 2013 and 2022 at our tertiary centre.
[Microorganisms isolated from blood cultures and resistance profile in children with cancer and high-risk febrile neutropenia. Red PINDA, Chile, 2016-2021].
Andes Pediatr
April 2024
Facultad de Medicina, Universidad de Chile, Santiago, Chile.
Unlabelled: Bacteremia is a major cause of morbidity and mortality in patients with cancer and episodes of high-risk febrile neutropenia (HRFN).
Objective: To identify the frequency of microorganisms isolated from blood cultures (BC) and their antimicrobial resistance (R) profile in children with HRFN, compared with the same data from previous studies of the same group.
Method: Prospective, multicenter, epidemiological surveillance study of microorganisms isolated from BC in patients under 18 years of age, from 7 PINDA network hospitals, between 2016 and 2021.
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