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Diagnostic and Therapeutic Approach to the Major Secondary Causes of Arterial Hypertension in Young Adults: A Narrative Review.
Cardiol Rev
October 2024
Barbra Streisand Women's Heart Center, Smidt Heart Institute, Cedars Sinai Medical Center, Los Angeles, CA.
Arterial hypertension in young adults, which includes patients between 19 and 40 years of age, has been increasing in recent years and is associated with a significantly higher risk of target organ damage and short-term mortality. It has been reported that up to 10% of these cases are due to a potentially reversible secondary cause, mainly of endocrine (primary aldosteronism, Cushing's syndrome, and pheochromocytoma/paraganglioma), renal (renovascular hypertension due to fibromuscular dysplasia and renal parenchymal disease), or cardiac (coarctation of the aorta) origin. It is recommended to rule out a secondary cause of high blood pressure (BP) in those patients with early onset of grade 2 or 3 hypertension, acute worsening of previously controlled hypertension, resistant hypertension, hypertensive emergency, severe target organ damage disproportionate to the grade of hypertension, or in the face of clinical or biochemical characteristics suggestive of a secondary cause of hypertension.
View Article and Find Full Text PDFLong-Term Cardiovascular Complications in Patients With Pheochromocytomas and Paragangliomas After Surgery: A Large Multi-Center Study.
Clin Endocrinol (Oxf)
December 2024
Department of Urology, Shengjing Hospital of China Medical University, Shenyang, China.
Objective: The effects of pheochromocytomas and paragangliomas (PPGLs)-induced catecholamine overproduction on vascular and cardiac function are generally thought to be reversible after PPGLs removal. However, a sizable proportion of patients who were free of the recurrent disease still faced high risks of cardiovascular problems after successful surgery. We aim to identify incidence and risk factors for long-term cardiovascular complications in PPGLs patients after surgery.
View Article and Find Full Text PDFKnockdown of IGF2BP3 Down-Regulates PDCD4 Levels to Attenuate Hypoxic-Ischemic Brain Damage.
Front Biosci (Landmark Ed)
September 2024
Department of Neonatology, Longhua District Central Hospital, 518110 Shenzhen, Guangdong, China.
Background: Hypoxic-ischemic brain damage (HIBD) is a prevalent brain injury with high mortality and morbidity. It results from hypoxia and ischemia of the brain due to various perinatal factors. A previous study showed that knockdown of programmed cell death factor 4 (PDCD4) could reduce infarction injury resulting from ischemia/reperfusion injury.
View Article and Find Full Text PDFCardiogenic shock in phaeochromocytoma multisystem crisis: a case report.
Eur Heart J Case Rep
September 2024
Department of Endocrinology, Sengkang General Hospital, 110 Sengkang E Wy, Singapore 544886, Singapore.
Background: Phaeochromocytoma multisystem crisis (PMC) is characterized by labile blood pressures (extremes of hypo- and/or hypertension) and multiorgan failure as a result of catecholamine excess. Initial stabilization requires pharmacological and/or mechanical circulatory support, followed by the institution of antihypertensives to correct the underlying pathophysiology.
Case Summary: A previously well 40-year-old male developed a sudden onset of breathlessness.
Complex Presentation of Pheochromocytoma: Hypertensive Encephalopathy and Takotsubo-Like Cardiomyopathy in a Young Female.
Am J Case Rep
September 2024
Division of Cardiothoracic Surgery, Mayo Clinic, Jacksonville, FL, USA.
Article Synopsis
- Pheochromocytoma is a rare tumor that secretes catecholamines and can cause severe symptoms like high blood pressure, rapid heart rate, headaches, and sweating; timely diagnosis is crucial to prevent complications.
- A case study of a 25-year-old woman showed she presented with hypertensive encephalopathy and acute coronary syndrome linked to pheochromocytoma, which was later confirmed via imaging and biochemical tests.
- After targeted treatment and surgery to remove the tumor, the patient’s hypertension and symptoms fully resolved, underscoring the need to consider pheochromocytoma in cases of acute neurological and cardiac issues.
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