Behaviour of aminohexoses and sialic acids in subacute intoxication of guinea pigs with "Elocron 50 WP".

The behaviour of sialic acids and aminohexoses was examined in subacute intoxication of 60 guinea pigs with "Elocron 50 WP". Elocron 50 WP was administered in soy-bean oil emulsion by means of a stomach tube for 28 and 85 days. The daily dose was 1/3 LD50. Further animals were kept for 28 days on food sprayed with "Elocron 50 WP". These animals were kept in quarantine during the period of treatment. The sialic acid level was found to be increased in the liver and in the other examined organs (heart, brain, kidney, lung) and slightly decreased in the serum. The aminohexose level was increased in the heart, kidney and brain, and decreased in the liver and lungs, in the early stage of intoxication (28 days) and in the group of the so-called "fodder" animals. In the late stage of the intoxication (85 days) an increased content of aminohexoses was observed in the brain and in the kidney, the increase was very slight in the heart and brain, whereas in the lung tissue the aminohexose level was subnormal.