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Targeting Blood-Stage Malaria: Design, Synthesis, Characterization, In Vitro, and In Silico Evaluation of Pyrrolidinodiazenyl Chalcones.
Chem Biol Drug Des
March 2025
Department of Chemistry, Pondicherry University, Kalapet, Puducherry, India.
Malaria is a pervasive and deadly threat to the global population, and the resources available to treat this disease are limited. There is widespread clinical resistance to the most commonly prescribed antimalarial drugs. To address this issue, we synthesized a range of 4'-pyrrolidinodiazenyl chalcones using a covalent bitherapy approach to study their potential antimalarial properties.
View Article and Find Full Text PDFDifferential susceptibility of and clinical isolates from Ghana and Mali to current and lead discovery candidate antimalarial drugs.
Microbiol Spectr
March 2025
West African Centre for Cell Biology of Infectious Pathogens (WACCBIP), College of Basic and Applied Sciences, University of Ghana, Legon, Ghana.
Unlabelled: Non-falciparum species causing malaria in humans are considered neglected in the fight toward malaria elimination. Recent data highlight the increasing contribution of to malaria morbidity and mortality. In this study, the susceptibility of and to current antimalarial drugs was compared to advanced lead candidate drugs using field isolates.
View Article and Find Full Text PDFMosquito vector-borne diseases are one of the leading causes of mortality and morbidity across the globe. Current vector control strategies mainly rely on chemical insecticides, but their incessant usage has resulted in the development of resistance. Insecticidal agents of microbial origin have proven as good alternative tools for vector control of mosquito.
View Article and Find Full Text PDFIntrinsic multiplication rate variation of Plasmodium falciparum in clinical isolates prior to elimination in Malaysia.
Int J Parasitol
March 2025
Department of Infection Biology, London School of Hygiene and Tropical Medicine, Keppel St, London WC1E 7HT, UK. Electronic address:
Replication rates and virulence of pathogens are hypothesised to evolve in response to varying intensity of transmission and competition among genotypes. Under exponential growth conditions in culture, clinical isolates of the malaria parasite Plasmodium falciparum have variable intrinsic multiplication rates, but comparisons of samples from different areas are needed. To analyse parasites from an area of low endemicity, Malaysian clinical isolates cryopreserved prior to malaria elimination were studied.
View Article and Find Full Text PDFHematological Profile of Naturally Infected Long-Tailed Macaques (Macaca fascicularis) With Plasmodium Inui in Ex Situ Captivity Prior to Ex Vivo Cultivation.
J Med Primatol
April 2025
Primatology Study Program, Graduate School of IPB University, Bogor, Indonesia.
Background: Anemia, characterized by low hemoglobin, is a key malaria indicator. Malaria in non-human primates (NHPs) is often asymptomatic, requiring laboratory tests and microscopy for diagnosis. Hematological profiles are crucial for understanding NHP clinical conditions and supporting ex vivo Plasmodium culture for antimalarial testing.
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