Analysis of published date and his own findings in the course of follow-up of 658 patients with mandibular fractures, who lived under novel for them climatic and geographic conditions for various periods (up to 1 year, 1 to 3 years, 3 to 5 years, permanently) brought the author to a conclusion on the contribution of adaptation processes to the course of healing. Some characteristics of protein and mineral metabolism were tested over the course of healing; for objective assessment, the "desirability" function was used, and indexes based on this function suggested: inflammatory reaction index, metabolic index, regeneration index. Typical changes in the pattern of metabolism and relationship between the incidence of complications and adaptation period were revealed. The author emphasizes that treatment should be planned with due consideration for the adaptation disorders.

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