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Steroids and Malignancy Increase Local Heparanase and Decrease Markers of Osteoblast Activity in Bone Tissue Microcirculation.
Biomolecules
November 2024
Thrombosis and Hemostasis Unit, Rambam Health Care Campus, Haifa 3109601, Israel.
Bone metastasis and steroids are known to activate the coagulation system and induce osteoporosis, pathological bone fractures, and bone pain. Heparanase is a protein known to enhance the hemostatic system and to promote angiogenesis, metastasis, and inflammation. The objective of the present study was to evaluate the effects of steroids and malignancy on the coagulation factors and osteoblast activity in the bone tissue.
View Article and Find Full Text PDFFerroptosis: Regulatory mechanisms and potential targets for bone metabolism: A review.
Medicine (Baltimore)
September 2024
Gansu University of Traditional Chinese Medicine, Lanzhou, China.
Article Synopsis
- Bone homeostasis involves a balance between osteoblasts (which form bone) and osteoclasts (which break down bone), and disruptions in this balance can lead to diseases like osteoporosis and osteoarthritis.
- Ferroptosis, a type of cell death linked to lipid peroxidation and reactive oxygen species, has been shown to impact bone homeostasis, although its exact mechanisms are still unclear.
- Recent research highlights that factors like organelle dysfunction, alongside iron metabolism and antioxidant imbalances, play crucial roles in ferroptosis and its influence on bone health, offering potential new avenues for treating bone and joint diseases.
Salidroside: A Promising Agent in Bone Metabolism Modulation.
Nutrients
July 2024
Department of Biophysics, Physiology and Pathophysiology, Faculty of Health Sciences, Medical University of Warsaw, Chałubińskiego 5, 02-004 Warsaw, Poland.
, a long-lived herbaceous plant from the Crassulaceae group, contains the active compound salidroside, recognized as an adaptogen with significant therapeutic potential for bone metabolism. Salidroside promotes osteoblast proliferation and differentiation by activating critical signaling pathways, including bone morphogenetic protein-2 and adenosine monophosphate-activated protein kinase, essential for bone formation and growth. It enhances osteogenic activity by increasing alkaline phosphatase activity and mineralization markers, while upregulating key regulatory proteins including runt-related transcription factor 2 and osterix.
View Article and Find Full Text PDFIs endocrine surveillance important in the care of Duchenne Muscular Dystrophy? Results from a national survey to patients and families on endocrine complications.
eNeurologicalSci
September 2024
Division of Pediatric Endocrinology, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX, 75390, United States of America.
Glucocorticoids are standard of care for patients with Duchenne muscular dystrophy (DMD). Although prolonged exposure is associated with multiple endocrine side effects, current guidelines related to monitoring and management of endocrinopathies are suboptimal. We aim to explore community perceptions of endocrine related complications in patients with DMD, assess current level of understanding, and desire for further education.
View Article and Find Full Text PDFBone Augmentation With Alloplastic Graft Material in a Patient Under Bisphosphonate Therapy: A Case Report and Literature Review.
J Oral Implantol
August 2024
Department of Oral and Maxillofacial Surgery, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan.
Cases of relatively safe dental implant treatment in patients with low-volume bisphosphonate (BP) have been gradually reported. Although bone augmentation is commonly used when the bone volume is insufficient for implant placement, the studies and case reports regarding the safety of bone augmentation in patients treated with BP remain insufficient. Herein, we report a case wherein bone augmentation was performed after BP treatment with bone healing realized according to imaging, and we review the literature regarding BP and bone augmentation.
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