96 patients with a clinical diagnosis of Dissociative Identity Disorder were administered the Million Clinical Multiaxial Inventory-II. The most elevated personality disorder scales were Avoidant, Self-defeating, Borderline, and Passive-Aggressive personality disorders. Elevated Axis I scales included Dysthymia, Major Depression, Thought Disorder, and Anxiety Disorder. Million-II profiles of a patient before and after integration showed normalization of a previously pathological profile.
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http://dx.doi.org/10.2466/pr0.1995.76.3.895 | DOI Listing |
Background: Treatment with the RXR-specific agonist Bexarotene exerts neuroprotective effects in Alzheimer's disease (AD) mouse models by improving cognition and increasing Aβ clearance. At the transcriptional level, ligand-activated RXR receptors regulate gene networks linked to neural development, neuroinflammation, and metabolism. This study aimed to reveal the association between changes in chromatin architecture and transcriptional activity in the brain of Bexarotene-treated APP/PS1 mice.
View Article and Find Full Text PDFLife Sci
January 2025
Immuno-Endocrinology, Diabetes & Metabolism Laboratory, Instituto de Investigaciones en Medicina Traslacional (IIMT), CONICET - Universidad Austral, Pilar, Argentina; Facultad de Ciencias Biomédicas, , Universidad Austral, Pilar, Argentina. Electronic address:
Aims: Type 2 diabetes (T2D) is a prevalent metabolic disease linked to obesity and metabolic syndrome (MS). The glucolipotoxic environment (GLT) impacts tissues causing low-grade inflammation, insulin resistance and the gradual loss of pancreatic β-cell function, leading to hyperglycemia. We have previously shown that Compound A (CpdA), a plant-derived dissociative glucocorticoid receptor-modulator with inflammation-suppressive activity, displays protective effects on β-cells in type 1 diabetes murine models.
View Article and Find Full Text PDFHarv Rev Psychiatry
January 2025
From School of Social Sciences, University of New South Wales (Dr. Salter); Department of Psychology, Towson University (Dr. Brand); Harvard Medical School (Dr. Robinson); School of Medicine, University of Maryland (Dr. Loewenstein); The Leadership Council on Child Abuse & Interpersonal Violence, Towson, MD (Dr. Silberg); Faculty of Health Sciences, McMaster University (Dr. Korzekwa).
Recent global popularity of social media content about dissociative identity disorder (DID) has coincided with increased self-diagnosis among children and young people who have formed large online communities and presented in clinical settings seeking to affirm their self-diagnoses. We situate this phenomenon within a broader trend toward self-diagnosis due to the widespread visibility and accessibility of mental health content on social media. Social media propelled self-diagnosis raises particular questions for the study and treatment of DID due to long-standing debates over whether the condition is traumagenic, sociogenic, or iatrogenic.
View Article and Find Full Text PDFJ Trauma Dissociation
January 2025
Solo Private Practice, Wauwatosa, Wisconsin.
The abusive and/or neglectful relational mis-attunement disrupts ongoing developmental growth and binds attachments to abusive caregivers. This shame-based relational frame then becomes a template for subsequent relationships and self-definitions. Shame and dissociation combine to provide a paradoxical and powerful self-protective form of self-regulation via a dis-enlivened existence that enables people with DID to live with otherwise potentially dysregulating affects and relationships.
View Article and Find Full Text PDFCureus
November 2024
Department of Public Health and Environmental Medicine, The Jikei University School of Medicine, Tokyo, JPN.
Little is known about the effectiveness of pharmacotherapy in dissociative identity disorder (DID). Zinc is essential for proper brain function. Its deficiency can lead to mental health symptoms, possibly contributing to dissociation.
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