Objectives: beta 2-microglobulin (beta 2-m) is a small molecular weight protein (11 800 Daltons) which can transudate into the cerebrospinal fluid (CSF) in the same manner than albumin. Intrathecal synthesis is a sign of local immuno-stimulation and is correlated with immunoglobulin G. The aim of this study was to ascertain the relationship between beta 2-microglobulin levels in the CSF and neurological diseases.
Methods: beta 2-microglobulin was assayed in the CSF and blood using an immunoenzyme method in 64 patients with multiple sclerosis (n = 14), human immunodeficiency virus (HIV) infection (n = 5), meningitis (n = 12) or a peripheral neurological disease (n = 10) and in 7 control subjects.
Results: There was no overall correlation between beta 2-m in the CSF and blood levels (r = 0.35). In controls, beta 2-m CSF and blood levels were respectively 0.94 +/- 0.22 and 1.46 +/- 0.83 mg/l. beta 2-m was significantly higher in the CSF of patients with meningitis and in the HIV positive patients (4 +/- 3.5 and 3.69 +/- 2.06 mg/l respectively) (p < 0.05). Type of meningitis (bacterial or non-bacterial) had no effect on the CSF level. For the HIV patients, the CSF/blood ratio for beta 2-m was similar to that in controls due to a rise in both blood and CSF. Finally, in patients with multiple sclerosis, there was no significant change in CSF level of beta 2-m.
Conclusion: beta 2-microglobulin in cerebrospinal fluid was not found to be correlated with the neurological diseases studied and cannot be used as a diagnostic test.
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