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The Efficiency of Chitosan Against Tert Butylhydroquinone (TBHQ)-Induced Neurobehavioral Changes and Toxicity Effects in Male Rats.
Front Biosci (Landmark Ed)
January 2025
Department of Zoology, College of Science, King Saud University, 11451 Riyadh, Saudi Arabia.
Background: We investigated chitosan's protective effects against tertiary butylhydroquinone (TBHQ)-induced toxicity in adult male rats, focusing on cognitive functions and oxidative stress in the brain, liver, and kidneys.
Methods: Rats were divided into four groups (n = 8/group): (1) Control, (2) Chitosan only, (3) TBHQ only, and (4) Chitosan + TBHQ.
Results: TBHQ exposure led to significant cognitive impairments and increased oxidative stress, marked by elevated malondialdehyde (MDA) and decreased superoxide dismutase (SOD) and glutathione (GSH) levels.
Amphotericin B Encapsulation in Polymeric Nanoparticles: Toxicity Insights via Cells and Zebrafish Embryo Testing.
Pharmaceutics
January 2025
Programa de Pós-Graduação em Pesquisa Translacional em Fármacos e Medicamentos (PPG-PTFM), Fundação Oswaldo Cruz (Fiocruz), Rio de Janeiro 21040-900, Brazil.
Amphotericin B (AmB) is a commonly utilized antifungal agent, which is also recommended for the treatment of certain neglected tropical diseases, including leishmaniasis. However, its clinical application is constrained because of its poor oral bioavailability and adverse effects, prompting the investigation of alternative drug delivery systems. Polymeric nanoparticles (PNPs) have gained attention as a potential drug delivery vehicle, providing advantages such as sustained release and enhanced bioavailability, and could have potential as AmB carriers.
View Article and Find Full Text PDFCurcumin-Loaded Lipid Nanoparticles: A Promising Antimicrobial Strategy Against in Endodontic Infections.
Pharmaceutics
January 2025
Laboratório Associado para a Química Verde-Rede de Química e Tecnologia (LAQV, REQUIMTE), Instituto de Ciências Biomédicas de Abel Salazar, Universidade do Porto, Rua de Jorge Viterbo Ferreira 228, 4050-313 Porto, Portugal.
This study aims to evaluate the efficacy of curcumin (CUR), a natural polyphenol with potent antimicrobial and anti-inflammatory properties, when formulated as solid lipid nanoparticles (CUR-loaded SLN) against . Solid lipid nanoparticles (SLNs) were prepared as a carrier for CUR, which significantly improved its solubility. SLNs made with cetyl palmitate and Tween 80 were obtained via the hot ultrasonication method.
View Article and Find Full Text PDFNanoformulation of Polymyxin E Through Complex Coacervation: A Pharmacokinetic Analysis.
Pharmaceutics
January 2025
Center for Pharmacy, University of Bergen, 5020 Bergen, Norway.
Polymyxin E (PME), a polymyxin antibiotic, serves as a final resort against antibiotic resistance. Nephrotoxicity is the primary concern when employing PME. To alleviate this issue, researchers have explored strategies including dosing adjustments and innovative formulations.
View Article and Find Full Text PDFEffects of Printing Orientation on the Tensile, Thermophysical, Smoke Density, and Toxicity Properties of Ultem 9085.
Polymers (Basel)
January 2025
Institute of Chemistry and Chemical Technology, Faculty of Natural Sciences and Technology, Riga Technical University, P. Valdena 3, LV-1048 Riga, Latvia.
Despite the impressive properties of additively manufactured products, their inherent anisotropy is a crucial challenge for polymeric parts made via fused filament fabrication (FFF). This study compared the tensile, thermophysical, smoke density, and toxicity characteristics of Ultem 9085 (a blend of polyetherimide and polycarbonate) for samples printed in various orientations (X, Y, and Z). The results revealed that mechanical properties, such as elastic modulus and tensile strength, significantly differed from the Z printing orientation, particularly in the X and Y printing layer orientations.
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