Characterization of group A streptococci isolated in Kuala Lumpur, Malaysia.

J Trop Med Hyg

National Streptococcus Reference Laboratory, Faculty of Medicine, National University of Malaysia.

Published: October 1995

AI Article Synopsis

  • T-agglutination patterns were examined in 190 group A streptococci strains collected from various body fluids between 1989 and 1993, revealing a mucoid morphology in 6.3% of the strains.
  • The most common T-types identified were T-5,11,27,44 (23.7%), with 42% of the strains remaining uncharacterized by T agglutination.
  • Further testing on 71 selected strains showed low M-typing results, with only three strains M-typeable and a significant production of serum opacity factor in 68% of isolates, indicating uncharacterized serotypes may exist in the region.

Article Abstract

T-agglutination patterns of 190 strains of group A streptococci isolated between January 1989 and December 1993 from body fluids (10), throat culture (56), pus (51) and skin lesions (73) were determined. Mucoid colonial morphology was exhibited by 6.3% (12/190) of the strains on initial isolation. Type T-5,11,27,44 comprised 23.7%, followed by T-1,3,13,B3264 (11.1%), T-4,6 (8.4%) and T-8,25, Imp 19 (7.9%). About 42% (80/190) strains could not be characterized by T agglutination pattern. T-typing of 71 selected strains at WHO Collaborating Center, Minneapolis yielded similar results. Nineteen selected strains were further characterized by M-typing; only three strains were M-typeable. These strains were isolated from throat (M1), sputum (M5) and pus (M12). About 68% (48/71) isolates produced serum opacity factor. These data support the existence of as yet uncharacterized group A streptococcal serotypes in this region.

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