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Sebaceous carcinoma in immunosuppressed patients: a narrative review.
Arch Dermatol Res
January 2025
Department of Dermatology, Columbia University Irving Medical Center, 161 Ft Washington Ave, 12th Floor, New York, NY, 10032, USA.
Sebaceous carcinoma is a rare cutaneous malignancy of sebaceous glands, but it is up to 25-fold more common in immunosuppressed individuals. In this narrative review, we examine the current literature on the pathogenesis, incidence, risk factors, prognosis, treatment, and surveillance of sebaceous carcinoma in immunosuppression and highlight practical considerations for providers who care for these patients. Increased incidence may be related to decreased immune surveillance, susceptibility to an unknown viral trigger, microsatellite instability, immunosuppressive medications, and unmasking of occult Muir-Torre Syndrome.
View Article and Find Full Text PDFClinical Features and Prognosis of Malignant Cutaneous Adnexal Tumors: A Retrospective Study Using a Japanese Database.
J Surg Oncol
December 2024
Division of Health Services Research, Institute for Cancer Control, National Cancer Center, Tokyo, Japan.
Malignant cutaneous adnexal tumors (MCATs) are rare. Previous population-based studies to determine the clinical features and prognosis of MCATs mainly included Caucasian patients, and the characteristics of Asian patients with MCATs have not yet been investigated. We aimed to investigate the characteristics of Asian patients with MCAT using a Japanese database.
View Article and Find Full Text PDFSebaceous carcinoma of the back: a case report and literature review.
J Med Case Rep
November 2024
Department of Surgery, School of Medicine, Pontificia Universidad Javeriana, Hospital Universitario San Ignacio, Bogotá D.C., Colombia.
Article Synopsis
- Extra ocular sebaceous carcinoma is a rare and aggressive tumor that arises from sebaceous glands, accounting for about 25% of sebaceous carcinomas, and is often challenging to diagnose due to its atypical appearance.
- A 69-year-old woman was diagnosed with a sebaceous carcinoma on her back, which presented as a large, ulcerated lesion, and was confirmed through a biopsy; she underwent surgical excision and sentinel lymph node biopsy.
- This case highlights that sebaceous carcinoma can appear in unusual locations, such as the back, and underscores the importance of surgical intervention as the primary treatment method, while noting that sentinel lymph node biopsy may be a less invasive alternative for staging.
Comparative educational effectiveness of AI generated images and traditional lectures for diagnosing chalazion and sebaceous carcinoma.
Sci Rep
November 2024
Department of Ophthalmology, Cancer Institute Hospital, Tokyo, Japan.
Sebaceous carcinoma is difficult to distinguish from chalazion due to their rarity and clinicians' limited experience. This study investigated the potential of AI-generated image training to improve diagnostic skills for these eyelid tumors compared to traditional video lecture-based education. Students from Orthoptics, Optometry, and Vision Research (n = 55) were randomly assigned to either an AI-generated image training group or a traditional video lecture group.
View Article and Find Full Text PDFCase report: A rare case of oral sebaceous carcinoma in the upper lip.
Pathol Oncol Res
November 2024
King Abdulaziz Medical City, Prince Noorah Oncology Center, Jeddah, Saudi Arabia.
Article Synopsis
- Sebaceous carcinoma (SC) is a rare and aggressive skin cancer that develops in the sebaceous glands, with few documented cases occurring on the lips.
- A 47-year-old male smoker presented with a painless, irregularly shaped mass on his upper lip that was biopsied, revealing malignant basaloid cells with sebaceous differentiation.
- The case highlights the unique characteristics of SC, including its histogenesis and treatment options, while emphasizing the importance of further research due to its rarity.
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