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Neuromyelitis Optica Spectrum Disorder With Unilateral Retrobulbar Neuritis: A Case Report.
Cureus
December 2024
Neurology and Neuroscience, Medical University of Varna, Varna, BGR.
Neuromyelitis optica spectrum disorder (NMOSD) includes conditions with autoimmune genesis, which are manifested by attacks of optic neuritis (ON) and transverse myelitis (TM), and also express aquaporin 4 (NMO-IgG) or myelin oligo-endocytic glycoprotein (MOGAb) antibodies. In rare cases, the disease may also have a clinical presentation with only TM, without ON or with ON, without TM. These conditions are also included in the spectrum.
View Article and Find Full Text PDFIntegrating palliative care into multiple myeloma management : Optimizing quality of life across the disease continuum.
Wien Klin Wochenschr
September 2024
Department of Medicine I, Division Hematology and Hemostaseology, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria.
Article Synopsis
- Multiple myeloma (MM) presents complex symptoms that require comprehensive management, and palliative care (PC) plays a crucial role in meeting patients' physical, psychosocial, and spiritual needs, though it is underutilized in MM treatment.
- A study of 22 MM patients in a palliative care unit found that the most common admission reasons were nutritional issues (82%), fatigue (77%), and pain (68%), with a significant portion dying during their stay.
- Results showed that while hospital stays varied, there was a notable reduction in symptom severity, highlighting the effectiveness of PC interventions in improving patients' quality of life through a multidimensional approach.
The akinetic crisis in Parkinson´s disease- the upper end of a spectrum of subacute akinetic states.
J Neural Transm (Vienna)
October 2024
Department of Neurology, LMU University Hospital, Ludwig-Maximilians-Universität (LMU) München, Munich, Germany.
Article Synopsis
- The akinetic crisis is a severe, potentially life-threatening condition in Parkinson's disease characterized by extreme rigidity and akinesia that does not respond to levodopa, often accompanied by high fever and altered consciousness.
- Although akinetic crises are rare, milder forms of motor deterioration in Parkinson's patients frequently lead to hospitalizations, highlighting the broader spectrum of akinetic symptoms.
- The review explores clinical symptoms, risk factors, diagnostic methods like DAT-SPECT for assessing levodopa-resistance, and discusses the role of inflammatory cytokines in progression, along with guidelines for managing these conditions.
Functioning and quality of life among treatment-engaged adults with psychotic disorders in urban Tanzania: Baseline results from the KUPAA clinical trial.
PLoS One
June 2024
Duke Global Health Institute, Duke University, Durham, NC, United States of America.
Background: There is a treatment gap for those living with severe mental illnesses in low- and middle-income countries, yet not enough is known about those who are currently accessing clinical services. A better understanding of potentially modifiable factors associated with functioning and quality of life will help inform policies and programming.
Aims: To describe the functioning and quality of life for a psychiatric treatment-engaged population living with psychotic disorders in two urban areas of Tanzania, and to explore their respective correlates.
Exploring the association between number of teeth, food intake, and cognitive function: A 9-year longitudinal study.
J Dent
June 2024
Department of Removable Prosthodontics and Gerodontology, Osaka University Graduate School of Dentistry, 1-8 Yamadaoka, Suita, Osaka 565-0871, Japan.
Objectives: This study aimed to investigate the association between the number of teeth, food intake, and cognitive function in Japanese community-dwelling older adults.
Methods: This 9-year longitudinal study included a total of 293 analyzable participants who participated in baseline and follow-up surveys. Dental status (number of teeth and periodontal pocket depth), dietary assessment using the brief-type self-administered diet history questionnaire, cognitive function, and the following confounding factors were evaluated: educational level, financial satisfaction, living situation, smoking and drinking habits, history of chronic diseases, apolipoprotein E-ε4 carrier, body mass index, handgrip strength, instrumental activities of daily living, and depressive symptomatology.
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