Resection of the rectum, with restoration of continuity by means of a primary, transanal, anocolic anastomosis, is a useful method in the treatment of certain rectal tumours. It particularly fills a need in the management of tumours of the lower rectum where anterior resection is indicated but is technically difficult and liable to complications, or where it is not possible and would be abandoned in favour of abdominoperineal excision of the rectum with a permanent colostomy. The pathological criteria, technical factors and functional results which justify the use of this procedure are discussed. The principles of the operation are described, and 2 illustrative cases are reported. The large size, low site and pathological nature of both the malignant carcinoid tumour and the leiomyoma were such that total rectal resection was obligatory, the object being palliation in the former and cure in the latter. Both patients were continent after the operation. The place of this operation in the treatment of adenocarcinoma of the rectum is discussed.
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Front Oncol
January 2025
Department of Colorectal Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin's Clinical Research Center for Cancer, Tianjin Key Laboratory of Digestive Cancer, Tianjin, China.
Background: Colorectal cancer (CRC) surgeries are commonly performed using either robotic-assisted colorectal surgery (RACS) or laparoscopic colorectal surgery (LCS). This study aimed to compare clinical and surgical outcomes between RACS and LCS for CRC patients.
Methods: We included 225 patients from Tianjin Medical University Cancer Institute & Hospital (TJMUCH) between January 2021 and June 2024, divided into RACS (n=82) and LCS (n=143) groups.
J Surg Case Rep
January 2025
Department of General Surgery, Royal Perth Hospital, 197 Wellington Street, Perth, Western Australia 6000, Australia.
Low anterior resection syndrome (LARS) is a challenging complication following sphincter-preserving rectal surgery, characterized by bowel dysfunctions such as urgency, frequency, and incontinence. This case series investigates the potential role of lactose intolerance in exacerbating LARS symptoms. Three patients who developed LARS after rectal resections showed persistent symptoms despite conventional management with bulking agents, physiotherapy, and loperamide.
View Article and Find Full Text PDFNat Commun
January 2025
University of Chicago, Department of Medicine, Chicago, IL, USA.
Total proctocolectomy with ileal pouch anal anastomosis is the standard of care for patients with severe ulcerative colitis. We generated a cell-type-resolved transcriptional and epigenetic atlas of ileal pouches using scRNA-seq and scATAC-seq data from paired biopsy samples of the ileal pouch and the ileal segment above the pouch (pre-pouch) from patients (male=4, female=2), and paired biopsies of the terminal ileum and ascending colon from healthy individuals (male=3, female=3) serving as reference. Our study finds an additional population of absorptive and secretory epithelial cells within the pouch but not the pre-pouch.
View Article and Find Full Text PDFDig Liver Dis
January 2025
Department of Medical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 17, Panjiayuan South Lane, Chaoyang District, Beijing 100021, China. Electronic address:
Background: Randomized studies have demonstrated that laparoscopic abdominoperineal resection is not inferior to open abdominoperineal resection for rectal cancer.
Aims: Evaluate the immediate and extended results of laparoscopic abdominoperineal resection versus open abdominoperineal resection for rectal cancer.
Methods: From January 2006 to December 2017, a total of 1852 patients with rectal cancer who had undergone abdominoperineal resection were enrolled in this investigation.
Oncologist
January 2025
Division of Medical Oncology, Department of Medicine, University of Colorado School of Medicine, Aurora, CO 80045, United States.
Over the last decade, multiple clinical trials have demonstrated a survival benefit for liver transplantation in colorectal cancer with liver metastases. Additionally, advances in donor organ preservation have expanded organ availability affording the opportunity to expand indications for liver transplantation, such as colorectal cancer with unresectable liver metastases. Current data support comparable overall survival (OS) for liver transplantation for colorectal cancer with liver metastases compared with general liver transplantation recipients.
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