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A novel technique of cryodenervation for murine vagus nerve: implications for acute lung inflammation.
Respir Res
January 2025
Department of Pulmonary and Critical Care Medicine, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, 200092, China.
Background: Neuroimmune interaction is an underestimated mechanism for lung diseases, and cryoablation is a competitive advantageous technique than other non-pharmacologic interventions for peripheral nerve innervating the lung. However, a lack of cryodenervation model in laboratory rodents leads to the obscure mechanisms for techniques used in clinic.
Method: Herein, we developed a novel practical method for mouse peripheral nerve cryoablation, named visualized and simple cryodenervation (VSCD).
GABALAGEN Facilitates Pentobarbital-Induced Sleep by Modulating the Serotonergic System in Rats.
Curr Issues Mol Biol
October 2024
Department of Physiology, College of Medicine, Kyung Hee University, Seoul 02447, Republic of Korea.
Article Synopsis
- GABA is an inhibitory neurotransmitter with unclear effects on sleep from oral ingestion, leading to the investigation of GABALAGEN (GBL), a GABA-enriched product derived from fermented collagen.
- The study used pentobarbital-induced sleep in rats to assess GBL's sedative effects through EEG analysis and evaluated its interaction with serotonin (5-HT) receptors and orexin levels in the brain.
- Results showed that GBL increases non-rapid eye movement sleep, influences serotonin levels, and impacts orexin expression, suggesting its sedative effects may be related to serotonergic system activation.
Mechanism of action of Panax ginseng alcohol extract based on orexin-mediated autophagy in the treatment of sleep and cognition in aged sleep-deprived rats.
J Ethnopharmacol
January 2025
College of Traditional Chinese Medicine, Changchun University of Chinese Medicine, Changchun, 130117, China; Northeast Asia Research Institute of Traditional Chinese Medicine, Changchun University of Chinese Medicine, Changchun, 130117, China; Key Laboratory of Ginseng Efficacy Substance Base and Biological Mechanism Research, Ministry of Education, Changchun University of Chinese Medicine, Changchun, 130117, China. Electronic address:
Article Synopsis
- Panax ginseng alcohol extract (GAE) has been recognized for its therapeutic benefits in improving sleep and cognitive function, particularly as a natural alternative for treating insomnia.
- The study aimed to explore how GAE affects sleep and cognition in aged sleep-deprived rats, focusing on the mechanism related to orexin-mediated autophagy.
- Results indicated that GAE significantly enhanced sleep duration and cognitive abilities, protected against neuronal damage in the hippocampus, and positively influenced various biological markers related to sleep and aging.
Extracts of Prunella vulgaris Enhanced Pentobarbital-Induced Sleeping Behavior in Mice Potentially via Adenosine A2A Receptor Activity.
Planta Med
September 2024
Uimyung Research Institute for Neuroscience, Department of Pharmacy, Sahmyook University, Seoul, Republic of Korea.
The increasing prevalence of sleep dysregulation cases has prompted the search for effective and safe sleep-enhancing agents. Numerous medications used in the treatment of sleep disorders function by enhancing -aminobutyric acid neurotransmitter activity. Unfortunately, these substances may induce significant adverse effects in chronic users, such as dependence and motor behavior impairments.
View Article and Find Full Text PDFMechanism of action of the Banxia-Xiakucao herb pair in sleep deprivation: New comprehensive evidence from network pharmacology, transcriptomics and molecular biology experiments.
J Ethnopharmacol
November 2024
Sleep Medicine Center, Hangzhou TCM Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou, 310007, China. Electronic address:
Article Synopsis
- Chinese herb pairs, like Banxia-Xiakucao (BXHP), are important in traditional Chinese medicine and help treat health problems with few side effects, especially insomnia.
- This study looked at how BXHP works to help with sleep issues using different scientific methods like testing on rats and studying the ingredients.
- The results showed that BXHP helps people sleep better, reduces anxiety, and balances certain hormones and chemicals in the body.
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