The data on the effect of MIGI-K preparation, acidic hydrolyzate from mussel meat, on organism resistance are presented. The effect is based on the ability of MIGI-K to influence the level of endogenous compounds responsible for radioresistance, such as biogenic amines and lipid hydroperoxides, as well as certain parameters determining immune status of organism.
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Experimental studies of the mussel hydrolyzate (MIGI-K) have shown that this preparation can enhance both general and radiation resistance of the organism. Moreover, MIGI-K promotes elimination of incorporated radionuclides from the organism. Some properties of this preparation, in particular, the absence of toxicity or harmful side effects, have made it possible to apply MIGI-K as an adaptogen, that is, a food supplement oftherapeutic and preventive action used to increase radionuclide excretion in the Chernobyl emergency clean-up workers.
View Article and Find Full Text PDFProphylactic peroral use of MIGI-K preparation (products of acid hydrolysis of mussels meat) largely or completely prevented intensification of lipoperoxidation and depression of antioxidative systems (superoxide dismutase, glutathione peroxidase, nonprotein thiols, lipoantioxidants) in skin and liver of UV-irradiated rats.
View Article and Find Full Text PDF[Effect of mussels hydrolysate MIGI-K on the adaptive response od bone marrow hematopoietic stem cells in mice].
Radiats Biol Radioecol
July 1999
Moscow State University, Department of Biology.
Radioprotective action of MIGI-K hydrolysate on adaptive response was studied. It was shown that this preparation protecting animals under lethal and sub-lethal doses of irradiation can also modify adaptive response. It was supposed that adaptive response model can be applied for studying possibilities of radioprotectors' use under low doses irradiation.
View Article and Find Full Text PDF[Adaptogen MIGI-K in rehabilitation of Chernobyl liquidators].
Radiats Biol Radioecol
July 1999
Moscow State University, Department of Biology.
Experimental studies of the mussels hydrolysate (MIGI-K) have shown that this preparation can enhance the radioresistance and general resistance of the organism. The mechanisms of its action are related mainly with its influence on the components of the biochemical back-ground of the resistance and with its antioxidative activity. Some properties of this preparation, for example, absence of toxicity and harmful side effects, made it possible as an adaptogene and as a remedy, increasing radionuclides excretion.
View Article and Find Full Text PDFAddition of mutilus hydrolysate MIGI-K to rations of minks with virus plasmacytosis involving grave immunological disorders led to changes in the ratio of serum protein fractions and in the differential blood count. Normalization of the protein spectrum of minks with Aleutian disease apparently inhibits the development of disorders caused by hypergammaglobullnemia.
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