Background: Documentation of the retinal nerve fiber layer using red free light is not established as a routine method. The reasons for this are the difficulties involved in taking the pictures and developing them, especially in glaucoma patients, and the need for maximum pupil dilation. The scanning laser ophthalmoscope (SLO) allows fast and easy documentation of the fundus with the possibility of simultaneous image control during the examination.
Patients And Methods: Nerve fiber layer images of 48 eyes of 25 patients taken with the argon blue light of the SLO were compared to conventional photographs of the nerve fiber layer with red-free light. In addition, we compared documentation of the nerve fiber layer using argon-blue or argon-green light in the SLO.
Results: The nerve fiber layer images obtained with the SLO were of good quality for all 48 eyes included in the study, whereas with conventional photography we could not obtain images in 9 eyes. There was a high correlation between the two methods in the detection of localized damage or zones with diffuse nerve fiber atrophy for the 39 eyes documented with both methods, and there was better image quality in some using the SLO. The use of blue light permits the nerve fiber layer to be seen more easily than with green light.
Conclusions: The SLO allows nerve fiber bundle defects or diffuse atrophy to be detected similar to conventional fundus photographs using red free light sources. There is no further need to dilate the pupil maximally due to the confocal principle and the scanning technique. The smaller angle of view of the SLO requires fixation movements of the patient being examined for the detection of beginning peripheral nerve fiber bundle defects.
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Vestn Oftalmol
December 2024
Krasnov Research Institute of Eye Diseases, Moscow, Russia.
This lecture-format review presents a summary of methods for assessing the condition of corneal nerve fibers (CNF), their clinical significance, and an overview of their anatomy and physiology. It briefly analyzes the structural and functional characteristics of CNF in various ocular diseases, following eye surgeries, and in patients with systemic diseases accompanied by systemic polyneuropathy. The article describes in detail the management algorithm that involves a comprehensive analysis of CNF and Langerhans inflammatory cells, identifies the at-risk groups for developing structural nerve impairments, and outlines the main criteria for CNF assessment.
View Article and Find Full Text PDFActa Ophthalmol
December 2024
Department of Ophthalmology and Optometry, Medical University of Vienna, Vienna, Austria.
Purpose: The relationship between retinal morphology, as assessed by optical coherence tomography (OCT), and retinal function in microperimetry (MP) has not been well studied, despite its increasing importance as an essential functional endpoint for clinical trials and emerging therapies in retinal diseases. Normative databases of healthy ageing eyes are largely missing from literature.
Methods: Healthy subjects above 50 years were examined using two MP devices, MP-3 (NIDEK) and MAIA (iCare).
BMC Musculoskelet Disord
December 2024
Physical medicine & rehabilitation research center, School of medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Background: Pompe disease is a glycogen storage disease primarily affecting striated muscles. Despite its main manifestation in muscles, patients with Pompe disease may exhibit non-muscle symptoms, such as hearing loss, suggesting potential involvement of sensory organs or the nervous system due to glycogen accumulation.
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Sci Rep
December 2024
Bascom Palmer Eye Institute, University of Miami, 900 NW 17th St, Miami, FL, USA.
This study assessed the impact of race and ethnicity on longitudinal test variability and time to detect glaucoma progression using standard automated perimetry (SAP) and optical coherence tomography (OCT). The sample consisted of 47,003 SAP tests from 5402 eyes and 25,480 OCT tests from 4125 eyes, with 20% of participants self-identifying as Black or African American and 80% as White; 29% as Hispanic or Latino and 71% as Not Hispanic or Latino. Variability was measured using standard deviations of residuals from linear regression models for SAP mean deviation (MD) and OCT retinal nerve fiber layer (RNFL) thickness over time.
View Article and Find Full Text PDFToxins (Basel)
November 2024
Institut des Neurosciences Paris-Saclay, UMR 9197, CNRS/Université Paris-Sud, 91198 Gif-sur-Yvette, Cedex, France.
Botulinum neurotoxin type-A (BoNT/A), which blocks quantal acetylcholine (ACh) release at the neuromuscular junction (NMJ), has demonstrated its efficacy in the symptomatic treatment of blepharospasm. In 3.89% of patients treated for blepharospasm at Tenon Hospital, BoNT/A was no longer effective in relieving the patient's symptoms, and a partial upper myectomy of the muscle was performed.
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