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The Impact of Targeted Therapies on Red Blood Cell Aggregation in Patients with Chronic Lymphocytic Leukemia Evaluated Using Software Image Flow Analysis.
Micromachines (Basel)
January 2025
Center of Competence at Mechatronics and Clean Technologies-MIRACle, "Acad. G. Bontchev" Str. 4, 1113 Sofia, Bulgaria.
Chronic lymphocytic leukemia (CLL), the most common type of leukemia, remains incurable with conventional therapy. Despite advances in therapies targeting Bruton's tyrosine kinase and anti-apoptotic protein BCL-2, little is known about their effect on red blood cell (RBC) aggregation in blood flow. In this study, we applied a microfluidic device and a newly developed Software Image Flow Analysis to assess the extent of RBC aggregation in CLL patients and to elucidate the hemorheological effects of the commonly applied therapeutics Obinutuzumab/Venetoclax and Ibrutinib.
View Article and Find Full Text PDFHematological and biochemical parameters correlated to hemorheology in Canine Monocytic Ehrlichiosis.
Rev Bras Parasitol Vet
January 2025
Programa de Pós-graduação em Ciências Veterinárias, Faculdade de Medicina Veterinária - FAVET, Universidade Federal de Mato Grosso - UFMT Cuiabá, MT, Brasil.
Canine monocytic ehrlichiosis (CME) is an infectious disease that causes hematological changes in dogs. This study investigated the correlations between hematological and hemorheological parameters, serum proteins, and triglycerides in dogs with CME. Fifty-nine blood and/or bone marrow samples were collected from dogs with or without clinical signs of CME.
View Article and Find Full Text PDFRecent Advances in Micro/Nanomotor for the Therapy and Diagnosis of Atherosclerosis.
ACS Appl Mater Interfaces
December 2024
Department of Laboratory Medicine, Liuzhou Key Laboratory of Precision Medicine for Viral Diseases, Guangxi Health Commission Key Laboratory of Clinical Biotechnology (Liuzhou People's Hospital), Liuzhou People's Hospital, Liuzhou 545006, China.
Article Synopsis
- - Atherosclerotic cardiovascular disease is a major global health issue leading to high rates of death and disability, with traditional treatments often harming other body parts.
- - Micro/nanomotors are tiny, self-propelled devices that can navigate the bloodstream, targeting problematic areas like atherosclerotic plaques and improving treatment effectiveness.
- - This review examines recent advances in micro/nanomotor technology for treating atherosclerotic disease, their potential in imaging plaques, and the need for personalized treatment approaches that consider individual patient factors.
Microbiome-metabolome analysis insight into the effects of high-salt diet on hemorheological functions in SD rats.
Front Nutr
September 2024
School of Health Preservation and Rehabilitation, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.
The present study examined the effect of two dietary regimens with elevated salt concentrations (4% and 8% salt) on hemorheological functions of SD rats, and explored the underlying mechanisms mainly through microbiome-metabolome analysis. An 8% HSD substantially altered the hemorheological parameters, and compromised intestinal barrier integrity and reduced the short-chain fatty acid levels. The microbiome-metabolome analysis revealed that 49 genus-specific microorganisms and 156 metabolites showed a consistent trend after exposure to both 4% and 8% HSDs.
View Article and Find Full Text PDFInvestigation of Hemorheological Parameters in Ischemic Stroke Patients.
Int J Lab Hematol
February 2025
Department of Biophysics, University of Health Sciences, Hamidiye Faculty of Medicine, Istanbul, Turkey.
Background: The aim of this study is to determine whether there are any changes in hemorheological parameters, including whole blood viscosity (WBV), plasma viscosity, erythrocyte aggregation, and erythrocyte deformability, in acute ischemic stroke patients, and to establish their relationship with stroke etiology. The study also aims to observe the changes in these parameters, if any, over time and after treatment, and to assess the correlation between risk factors for ischemic stroke and neuroimaging findings.
Methods: This was a prospective observational study including 70 patients diagnosed with acute ischemic stroke within the first 3 days of the onset of symptoms and 96 healthy controls.
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