[Effects of high doses of aprotinin on intra- and postoperative blood loss in surgery with artificial circulation].

A total of 100 patients subjected to multiple aortocoronary shunting under artificial circulation were examined. All of them were administered aprotinin or placebo in standard doses in a double blind test. The drug was infused over the entire course of the operation, total dose being 6 million KIU. The groups of patients did not differ by duration of artificial circulation and aorta clamping, or by the number of shunts used. The data permit a conclusion that prolonged intraoperative infusion of aprotinin in a dose of 6 million KIU resulted in a twofold reduction of the blood loss during and after the operation, thus permitting less frequent and lower in volume transfusions of donor blood during the operation and in the early postoperative period.