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Tracing of Amino Acids Dynamics in Cell Lines Based on O Stable Isotope Labeling.
Anal Chem
January 2025
Hacettepe University, Faculty of Pharmacy, Department of Analytical Chemistry, Ankara 06230, Turkey.
Metabolite levels and turnover rates are necessary to understand metabolomic dynamics in a living organism fully. Amino acids can play distinct roles in various cellular processes, and their abnormal levels are associated with pathological conditions, including cancer. Therefore, their levels, especially turnover rates, may provide enormous information about a phenotype.
View Article and Find Full Text PDFSQSTM1/P62 Mediates the Effects of CPNE3 on the Epithelialmesenchymal Transition and Migratory Inhibition of Lung Adenocarcinoma Cells.
Curr Med Chem
January 2025
Medical Experimental Center, The First People's Hospital of Nanning, The Fifth Affiliated Hospital of Guangxi Medical University, Nanning, 530022, China.
Introduction: Copine-3 (CPNE3) is a conservative calcium-dependent phospholipid-binding protein belonging to the copines protein family. CPNE3 has been implicated in the development and progression of several diseases, including cancer.
Method: Herein, we investigated the molecular mechanisms through which CPNE3 regulates the migration of lung adenocarcinoma (LUAD) cells in vitro.
FeO might be more suitable than Fe for the construction of anammox-dominated Fe-N coupling system: Based on N isotope tracing.
Water Res
January 2025
Beijing Key Laboratory of Aqueous Typical Pollutants Control and Water Quality Safeguard, School of Environment, Beijing Jiaotong University, Beijing, 100044, PR China. Electronic address:
Iron not only influences the activity of anammox bacteria (AnAOB) but also participates in complex Fe-N cycles. In this study, the advanced N isotope tracing method was set up to quantify the potential rates of full nitrogen metabolic pathways under different ferrous iron (Fe and FeO) within two identical anammox granular reactors. The results indicated that both Fe and FeO enhanced AnAOB activity.
View Article and Find Full Text PDFSingle Cell-Pair Proteomics for Decoding Immune-Cancer Cell Interactions.
Adv Sci (Weinh)
January 2025
Institute of Microanalytical Systems, Department of Chemistry, Zhejiang University, Hangzhou, 310058, China.
The efficacy of cancer immunotherapy is significantly influenced by the heterogeneity of individual tumors and immune responses. To investigate this phenomenon, a microfluidic platform is constructed for profiling immune-cancer cell interactions at the single-cell proteomics level for the first time. Based on the platform, a comprehensive workflow is proposed for achieving accurate single-cell pairing of an immune cell and a cancer cell with low cell damage and high success rate up to 95%, cell pair co-culture, and real-time microscopic monitoring of the cell-pair interactions, cell pair retrieval, mass spectrometry-based proteomic analysis of singe cell pairs, and decoupling of the proteomic information for each cell within the cell pair with the stable-isotope labeling method.
View Article and Find Full Text PDFMeasuring the Stable Isotope Composition of Water in Brine from Halite Fluid Inclusions and Borehole Brine Seeps Using Cavity Ring-Down Spectroscopy.
ACS Earth Space Chem
January 2025
Earth and Environmental Sciences Division, Los Alamos National Laboratory, Los Alamos, New Mexico 87545, United States.
Naturally occurring bedded salt deposits are considered robust for the permanent disposal of heat-generating nuclear waste due to their unique physical and geological properties. The Brine Availability Test in Salt (BATS) is a US-DOE Office of Nuclear Energy funded project that uses heated borehole experiments underground (∼655 meters depth) at the Waste Isolation Pilot Plant (WIPP) in the bedded salt deposits of the Salado Formation to investigate the capacity for safe disposal of high-level, heat generating nuclear waste in salt. Uncertainties associated with brine mobility near heat-generating waste motivates the need to characterize the processes and sources of brine in salt deposits.
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