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The topography of nullomer-emerging mutations and their relevance to human disease.
Comput Struct Biotechnol J
December 2024
Institute for Personalized Medicine, Department of Biochemistry and Molecular Biology, The Pennsylvania State University College of Medicine, Hershey, PA, USA.
Nullomers are short DNA sequences (11-18 base pairs) that are absent from a genome; however, they can emerge due to mutations. Here, we characterize all possible putative human nullomer-emerging single base pair mutations, population variants and disease-causing mutations. We find that the primary determinants of nullomer emergence in the human genome are the presence of CpG dinucleotides and methylated cytosines.
View Article and Find Full Text PDFIn-vitro assay studies and molecular docking of functionalized chitosan decorated vanadium pentoxide nano-agents as an antidiabetic drug.
Int J Biol Macromol
January 2025
Dept. of Chemistry, Netaji Subhas University of Technology (N.S.U.T.), erstwhile N.S.I.T., Azad Hind Fauj Marg, Dwarka, Delhi 110078, India. Electronic address:
This study aims to enhance the antidiabetic potential of Vanadium pentoxide (VO) by synthesizing chitosan-based nanoparticles (NPs). Chitosan and its derivatives were used to fabricate VO NPs, ensuring enhanced antioxidant and antidiabetic activity. Surface topography was analyzed using atomic force microscopy (AFM), revealing bioactive sites on the NPs with improved electron-transfer capability, as confirmed by cyclic voltammetry (CV).
View Article and Find Full Text PDFA Hierarchical Metal-Organic Framework Intensifying ROS Catalytic Activity and Bacterial Entrapment for Engineering Self-Antimicrobial Mask.
Adv Sci (Weinh)
December 2024
School of Chemical Engineering and Technology, Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai), Sun Yat-sen University, Zhuhai, 519082, P. R. China.
Article Synopsis
- The development of advanced personal protective equipment (PPE) using functional materials is crucial for preventing the spread of infectious diseases, but achieving effective antimicrobial properties remains a challenge.
- A newly reported hierarchically porous cerium metal-organic framework (Ce-MOF) significantly enhances antimicrobial performance by promoting the generation of reactive oxygen species (ROS) and effectively trapping bacteria.
- This innovative Ce-MOF design provides exceptional antimicrobial efficacy—nearly 100%—even in low-light conditions, paving the way for the creation of self-disinfecting PPE materials.
Extension of sticholysins N-terminal α-helix signals membrane lipids to acquire curvature for toroidal pore formation.
Biochem Biophys Res Commun
January 2025
Center of Protein Studies, Faculty of Biology, Havana University, Havana, Cuba.
Sticholysin I and II (St I/II) belong to the actinoporins family; these proteins form pores in host cell membranes by binding their N-terminal segment to the membrane, leading to protein-lipid (toroidal) pores. Peptides derived from actinoporins pore-forming domains replicate their folding properties and permeabilizing effects. Despite the advances in understanding how these proteins and peptides mediate pore formation, the role of different N-terminal segments in inducing membrane curvature is still unclear.
View Article and Find Full Text PDFNADH-dependent CO reductase on graphite for capacitive electrocatalytic interfacing mediated by solid-binding peptide.
Bioresour Technol
February 2025
School of Environment and Energy Engineering, Gwangju Institute of Science and Technology (GIST), 123 Cheomdan-gwagiro, Buk-gu, Gwangju 61005, Republic of Korea; Research Center for Innovative Energy and Carbon Optimized Synthesis for Chemicals (inn-ECOSysChem), Gwangju Institute of Science and Technology, 123 Cheomdan-gwagiro, Buk-gu, Gwangju 61005, Republic of Korea. Electronic address:
NAD/NADH-dependent CO reductase (CR) adapted from Candida methylica (E.C. 1.
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