Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/ajh.2830490218 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Sickle Cell Disease: A Potential Cause of Immune Thrombocytopenia.
Cureus
December 2024
Internal Medicine, King Fahad Hospital Hofuf, Hofuf, SAU.
Sickle cell anemia (SCA) is one of the known hemoglobinopathies that result in red blood cell (RBC) destruction, among other complications. There are factors that make SCA an environment for autoimmune disease (AID). They include chronic inflammation, immune-mediated processes involved in SCA complications, and susceptibility to infections.
View Article and Find Full Text PDFMigrasomes derived from human umbilical cord mesenchymal stem cells: a new therapeutic agent for ovalbumin-induced asthma in mice.
Stem Cell Res Ther
January 2025
Department of Nuclear Medicine, The Affiliated Hospital of Jiangsu University, Zhenjiang, 212000, Jiangsu, P. R. China.
Background: Asthma is a prevalent respiratory disease, and its management remains largely unsatisfactory. Mesenchymal stem cells (MSCs) have been demonstrated to be efficacious in reducing airway inflammation in experimental allergic diseases, representing a potential alternative treatment for asthma. Migrasomes are recently identified extracellular vesicles (EVs) generated in migrating cells and facilitate intercellular communication.
View Article and Find Full Text PDFFully automated in vivo screening system for multi-organ imaging and pharmaceutical evaluation.
Microsyst Nanoeng
January 2025
Guangdong Provincial Key Laboratory of Sensor Technology and Biomedical Instrument, School of Biomedical Engineering, Shenzhen Campus of Sun Yat-Sen University, 518000, Shenzhen, China.
Advancements in screening technologies employing small organisms have enabled deep profiling of compounds in vivo. However, current strategies for phenotyping of behaving animals, such as zebrafish, typically involve tedious manipulations. Here, we develop and validate a fully automated in vivo screening system (AISS) that integrates microfluidic technology and computer-vision-based control methods to enable rapid evaluation of biological responses of non-anesthetized zebrafish to molecular gradients.
View Article and Find Full Text PDFBoron-dependent autoinducer-2-mediated quorum sensing stimulates the Cr(VI) reduction of Leucobacter chromiireducens CD49.
J Environ Manage
January 2025
Department of Occupational and Environmental Health, Xiangya School of Public Health, Central South University, Changsha, China. Electronic address:
Traditionally, abiotic factors such as pH, temperature, and initial Cr(VI) concentration have been undoubtedly recognized as the external driving forces that dramatically affect the microbial-mediated remediation of Cr(VI) pollutants. However, concentrating on whether and how the biological behaviors and metabolic activities drive the microbial-mediated Cr(VI) detoxification is a study-worthy but little-known issue. In this study, Leucobacter chromiireducens CD49 isolated from heavy-metal-contaminated soil was identified to tolerate 8000.
View Article and Find Full Text PDFBetacoronaviruses Differentially Activate the Integrated Stress Response to Optimize Viral Replication in Lung-Derived Cell Lines.
Viruses
January 2025
Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
The betacoronavirus genus contains five of the seven human coronaviruses, making it a particularly critical area of research to prepare for future viral emergence. We utilized three human betacoronaviruses, one from each subgenus-HCoV-OC43 (embecovirus), SARS-CoV-2 (sarbecovirus), and MERS-CoV (merbecovirus)-, to study betacoronavirus interactions with the PKR-like ER kinase (PERK) pathway of the integrated stress response (ISR)/unfolded protein response (UPR). The PERK pathway becomes activated by an abundance of unfolded proteins within the endoplasmic reticulum (ER), leading to phosphorylation of eIF2α and translational attenuation.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!