Thirty-nine keratoacanthomas from 35 patients have been studied, six of which showed perineural, and one vascular, invasion. Thus far, their aggressive histological behavior has not been paralleled by a similar clinical course. However, continued close follow-up is essential.

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http://dx.doi.org/10.1111/j.1600-0560.1977.tb00926.xDOI Listing

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