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Non-additive dosage-dependent effects of TaGS3 gene editing on grain size and weight in wheat.
Theor Appl Genet
January 2025
Wheat Genetics Resource Center, Kansas State University, Manhattan, KS, USA.
Loss-of-function mutations induced by CRISPR-Cas9 in the TaGS3 gene homoeologs show non-additive dosage-dependent effects on grain size and weight and have potential utility for increasing grain yield in wheat. The grain size in cereals is one of the component traits contributing to yield. Previous studies showed that loss-of-function (LOF) mutations in GS3, encoding Gγ subunit of the multimeric G protein complex, increase grain size and weight in rice.
View Article and Find Full Text PDFPhenotypic and genomic characterization of Levilactobacillus brevis YT108: a potential probiotic strain capable of metabolizing xylo-oligosaccharides.
Lett Appl Microbiol
January 2025
Panxi Crops Research and Utilization Key Laboratory of Sichuan Province, Xichang University, Liangshan, China.
Levilactobacillus brevis YT108, identified for its ability to metabolize prebiotic xylo-oligosaccharides (XOS), emerges as a candidate for probiotic use in synbiotic food formulations. This study aimed to investigate the metabolic and genomic traits associated with XOS metabolism in YT108 and to assess its probiotic attributes through whole genome sequencing and in vitro assays. Strain YT108 exhibited robust growth kinetics on XOS as the sole carbon source, with a growth profile comparable to that on glucose, achieving a pH reduction to 4.
View Article and Find Full Text PDFInsights into diet, psychological distress, and personality traits among patients with lower-extremity lymphedema and overweight/obesity in comparison to patients with lifestyle-induced overweight/obesity and patients with normal body weight.
Obes Res Clin Pract
January 2025
Department of Angiology and Internal Medicine, Wroclaw Medical University, Wroclaw, Poland. Electronic address:
Obesity is a leading cause of cardiovascular diseases. There are significant and mutual associations between lymphatic dysfunction and obesity. This case-control study aimed to compare nutrient intake, depressive symptoms, and Eysenck's personality traits in patients with lower extremity lymphedema and overweight/obesity (n = 34) in comparison to patients with lifestyle-induced overweight/obesity (n = 30) and patients with normal body weight (n = 30).
View Article and Find Full Text PDFCRAmed: a conditional randomization test for high-dimensional mediation analysis in sparse microbiome data.
Bioinformatics
January 2025
Department of Statistics, School of Mathematical Sciences, Shanghai Jiao Tong University, Shanghai, 200240, China.
Motivation: Numerous microbiome studies have revealed significant associations between the microbiome and human health and disease. These findings have motivated researchers to explore the causal role of the microbiome in human complex traits and diseases. However, the complexities of microbiome data pose challenges for statistical analysis and interpretation of causal effects.
View Article and Find Full Text PDFOccurrence and allele frequencies of genetic variants associated with Varroa drone brood resistance (DBR) in African Apis mellifera subspecies.
J Invertebr Pathol
January 2025
Laboratory of Molecular Entomology and Bee Pathology (L-MEB), Department of Biochemistry and Microbiology, Faculty of Sciences, Ghent University, Ghent, Belgium.
The ectoparasite Varroa destructor is a major contributor to the global decline of honeybee colonies (Apis mellifera), especially in the Northern Hemisphere. However, Varroa-resistant honeybee populations have been reported in various regions around the globe, including Europe and Africa. This resistance is primarily attributed to the trait known as Suppressed Mite Reproduction (SMR), which significantly reduces the reproductive success of Varroa mites within these colonies.
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