On the basis of the assumption of an affinity between cerebral and retinal vessels, it was sought to demonstrate that the variations induced in the retinal circulation are akin to those occurring at the cerebral level. The technique of retinal fluorescein angiography was used to evaluate the amplitude of the vasal lumen and the speed of circulation. In 5 patients, the drug used was (-)eburnamonine. While the calibre of the retinal arterioles did not undergo variations, a shortening of the mean transit time was observed in 3 of the 5 cases treated, evidencing an improvement in blood flow.
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http://dx.doi.org/10.1159/000115007 | DOI Listing |
Ophthalmic Physiol Opt
January 2025
Robert O Curle Ophthalmology Suite, Institute for Regeneration and Repair, The University of Edinburgh, Edinburgh, UK.
Purpose: To determine whether imaging features derived from fundus photographs contain 3D eye shape information beyond that available from spherical equivalent refraction (SER).
Methods: We analysed 99 eyes of 68 normal adults in the UK Biobank. An ellipsoid was fitted to the entire volume of each posterior eye (vitreous chamber without the lens)-segmented from magnetic resonance imaging of the brain.
Ophthalmic Physiol Opt
January 2025
Northeastern University College of Science, Boston, Massachusetts, USA.
Purpose: To assess longitudinal changes in optical quality across the periphery (horizontal meridian, 60°) in young children who are at high (HR) or low risk (LR) of developing myopia, as well as a small subgroup of children who developed myopia over a 3-year time frame.
Methods: Aberrations were measured every 6 months in 92 children with functional emmetropia at baseline. Children were classified into HR or LR based on baseline refractive error and parental myopia.
Clin Genet
January 2025
Department of Medical Genetics, Medical Faculty, Aksaray University, Aksaray, Turkiye.
Inherited retinal diseases (IRDs) constitute a heterogeneous group of clinically and genetically diverse conditions, standing as a primary cause of visual impairment among individuals aged 15-45, with an estimated incidence of 1:2000. Our study aimed to comprehensively evaluate the genetic variants underlying IRDs in the Turkish population. This study included 50 unrelated Turkish IRD patients and their families.
View Article and Find Full Text PDFHandb Clin Neurol
January 2025
Centre for Chronobiology, Psychiatric Hospital of the University of Basel, Basel, Switzerland; Research Cluster Molecular and Cognitive Neurosciences, University of Basel, Basel, Switzerland; Department of Biomedicine, University of Basel, Basel, Switzerland.
The nonvisual effects of light in humans are mainly conveyed by a subset of retinal ganglion cells that contain the pigment melanopsin which renders them intrinsically photosensitive (= intrinsically photosensitive retinal ganglion cells, ipRGCs). They have direct connections to the main circadian clock in the suprachiasmatic nuclei (SCN) of the hypothalamus and modulate a variety of physiological processes, pineal melatonin secretion, autonomic functions, cognitive processes such as attention, and behavior, including sleep and wakefulness. This is because efferent projections from the SCN reach other hypothalamic nuclei, the pineal gland, thalamus, basal forebrain, and the brainstem.
View Article and Find Full Text PDFPhotodiagnosis Photodyn Ther
January 2025
Department of Ophthalmology, Ankara Bilkent City Hospital, University of Health Sciences, Ankara, Turkey.
Purpose: In this study, it was planned to compare the macular ganglion cell analysis (GCA) and peripapillary retinal nerve fiber layer (pRNFL) of the patients with preperimetric glaucoma (PPG), early stage glaucoma (EG) and the control group.
Methods: This retrospective study included a total of 103 eyes: 38 from EG patients, 30 from PPG patients, and 35 from healthy individuals at Ankara Bilkent City Hospital Glaucoma Unit between January 2018 and September 2021. Eyes were categorized into control, PPG, and EG groups based on visual field (VF) classification.
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