AI Article Synopsis
- The development of advanced libraries and selection methods has enabled the discovery of linear peptides that imitate complex epitope structures.
- Phage display techniques are being utilized to select peptides associated with diseases, effectively mimicking the properties of natural antigens by utilizing patient serum.
- The use of phage technology has broadened to identify peptides that interact with not only antibodies but also various molecules like cell receptors and enzymes.
Article Abstract
The construction of new and increasingly diverse libraries, as well as the implementation of more powerful selection schemes, has led to the identification of linear peptides that mimic complex epitopes. Phage display techniques are allowing the selection of disease-related peptides, which reproduce the antigenic and immunogenic properties of natural antigens, using whole sera from patients. The range of applications of phage technology has been extended to include the search for peptides binding to molecules other than antibodies, such as cell receptors and enzymes.
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| http://dx.doi.org/10.1016/0958-1669(95)80012-3 | DOI Listing |
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