The interactions of HIV-I reverse transcriptase with some alkaloids were studied. Among nine compounds tested three--berberine, palmatine and sanguiritrine--inhibited RT. The dependence of the inhibition on the type of template-primer was also demonstrated. The kinetic analysis as well as circular dichroism experiments suggest the complex mechanism of RT inhibition by alkaloids. This mechanism includes both enzyme-alkaloid and alkaloid-template interactions; the latter effect also results in RT inhibition.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
reverse transcriptase
8
[kinetic analysis
4
analysis interaction
4
interaction human
4
human immunodeficiency
4
immunodeficiency virus
4
virus reverse
4
transcriptase alkaloids]
4
alkaloids] interactions
4
interactions hiv-i
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!