The data on the study of antilysozyme and anti-interferon properties of 375 Klebsiella strains are presented. The heterogeneity of strains with respect to their antilysozyme and anti-interferon activity is described. As revealed in this study, these properties occur more frequently and considerably to a greater extent in strains isolated from patients with Klebsiella infections and from carriers. Strains, incapable of inhibiting lysozyme and interferon or capable to digest them poorly, prevail among strains isolated from healthy persons. The data on the relationship between the level of the persistence factors of Klebsiella and the source of their isolation are presented.
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Front Microbiol
January 2025
Department of Infection Management and Disease Control, The First Medical Center of Chinese PLA General Hospital, Beijing, China.
Background: We aimed to describe the epidemiology, cross-transmission, interventions, and outcomes of carbapenem-resistant (CRKP) infections in the hematological malignancies (HM) department of a hospital in China.
Methods: This prospective study was divided into three stages from 2014 to 2022: Period 1 (from 1 January 2014 to 4 March 2021), Period 2 (from 5 March 2021 to 31 December 2021), and Period 3 (from 1 January 2022 to 31 December 2022), with different measures implemented at each stage to evaluate the rate of new infections. The risk factors, epidemiological characteristics, data from all patients with CRKP, NGS gene sequencing molecular epidemiology analysis, and cross-transmission were described.
BMC Microbiol
January 2025
Department of Respiratory Medicine, Capital Medical University, Beijing, China.
Background: The clinical outcomes and microbiological features of lower respiratory tract infections (LRTIs) caused by hypervirulent Klebsiella pneumoniae (hvKp) and classical Klebsiella pneumoniae (cKp) have not been well understood.
Methods: This study collected 287 non-repetitive Klebsiella pneumoniae isolates from 287 LRTI patients. All these strains underwent annotation for resistance and virulence factors, with 141 strains undergoing mouse infection experiments to assess their virulence.
J Hosp Infect
January 2025
Department of Neurosurgery, Yale University School of Medicine, New Haven, CT 06510, USA. Electronic address:
Background: The health and well-being of refugees are critically compromised by harsh living conditions, which foster the emergence of infectious diseases and the misuse of antimicrobial agents. This multicentre cross-sectional community-based study investigated the prevalence of urine carriage of bacteria and the associated antimicrobial resistance patterns among Syrian refugees living in makeshift camps in Lebanon, an East Mediterranean country.
Methods: We used multivariable logistic regression models to identify the risk factors associated with bacteriuria in this vulnerable population.
J Environ Manage
January 2025
China Architecture Design and Research Group, Beijing, 100044, PR China; Center for Water and Ecology, State Key Joint Laboratory of Environment Simulation and Pollution Control, School of Environment, Tsinghua University, Beijing, 100084, PR China.
Slow sand filters (SSFs) have been increasingly applied to rainwater purification in recent years, but the response of SSFs to fluctuating rainfall, as well as the biofilm- and water-phase microecology in SSFs are still poorly understood. This study systematically evaluated the rainwater purification performance of SSFs and compared the bacterial community structure, assembly processes and molecular ecological interactions between the biofilm and water phases. The activated carbon and activated alumina filters exhibited the best performance for NH-N (18.
View Article and Find Full Text PDFFront Cell Infect Microbiol
January 2025
Center for Infectious Diseases Research (CIDR) and WHO Collaborating Center for Reference and Research on Bacterial Pathogens, American University of Beirut, Beirut, Lebanon.
Introduction: Multidrug resistant Gram-negative bacterial infections are considered a major public health threat. Immunocompromised pediatric patients are at a great risk of severe or overwhelming infections. The aim of this study was to describe the frequency of infections with multidrug resistant (MDR) Gram-negative bacteria (GNB) in immunocompromised pediatric patients and to determine the risk factors.
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