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Photosensitizer delivery for photodynamic therapy of choroidal neovascularization.
Adv Drug Deliv Rev
October 2001
Retina Service, Angiogenesis Laboratory, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA, USA.
The present review examines the importance of improving photosensitizer delivery for choroidal neovascularization (CNV) in light of the clinical impact of photodynamic therapy (PDT) for CNV. An overview of the classes of available photosensitizers is provided and the properties governing photosensitizer uptake and circulation in serum are discussed. Current delivery systems, for example liposomal formulations as well as the use of the promising strategy of antibody targeted delivery as a strategy to improve PDT selectivity and efficiency for CNV treatment are described.
View Article and Find Full Text PDFControl of fibroblast populated collagen lattice contraction by antibody targeted photolysis of fibroblasts.
Lasers Surg Med
November 1997
Center for Engineering in Medicine/Surgical Services, Massachusetts General Hospital, Boston 02114, USA.
Background And Objective: Hypertrophic scarring and rigid scar contracture are disorders of wound healing for which there is presently no effective therapy. The dermal fibroblast plays a major role in scar fibrillogenesis and contracture. The objective of this study was to establish a selective and effective method to destroy fibroblasts.
View Article and Find Full Text PDFControl of hypertrophic scar growth using antibody-targeted photolysis.
J Surg Res
April 1996
Surgical Services, Massachusetts General Hospital, Boston, 02114, USA.
Hypertrophic scar is marked by excess collagen accumulation secondary to an increased vascularization response in the scar and an increase in fibroblast cell density. It is currently the most debilitating long-term complication of the surviving burn patient, and at present, there is no routinely effective form of therapy. In this study, we investigated the potential use of antibody-targeted photolysis (ATPL) in treating hypertrophic scars.
View Article and Find Full Text PDFAntibody-targeted photolysis. Photophysical, biochemical, and pharmacokinetic properties of antibacterial conjugates.
Ann N Y Acad Sci
November 1994
Surgical Services, Massachusetts General Hospital, Boston 02114.
Antibody-targeted photolysis of bacteria in vivo.
Biotechnology (N Y)
July 1994
Surgical Services, Massachusetts Hospital, Boston.
We have evaluated the efficacy of antibody-targeted photolysis to kill bacteria in vivo using specific antibacterial photosensitizer (PS) immunconjugates. After infecting the dorsal skin in mice with Pseudomonas aeruginosa, both specific and nonspecific tin (IV) chlorin e6-monoclonal antibody conjugates were injected at the infection site. After a 15 min incubation period, the site was exposed to 630 nm light with a power density of 100 mW/cm2 for 1600 seconds.
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