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Creation and validation of an extended-spectrum beta-lactamase-producing Enterobacterales (ESBL-E) clinical risk scoring tool for select Enterobacterales in non-urinary isolates.
Pharmacotherapy
January 2025
Department of Pharmacy Services, Medical University of South Carolina Health, Charleston, South Carolina, USA.
Background: Infections caused by extended-spectrum β-lactamase-producing Enterobacterales (ESBL-E) are increasing in the United States. Although many risk factor scoring tools exist, many are specific to bloodstream isolates and may not represent all patient populations. The purpose of this study was to create and validate an institution-specific scoring tool for select ESBL-E of non-urinary origin based on previously identified risk factors.
View Article and Find Full Text PDFMultidrug-Resistant Strains in a Hospital: Phylogenetic Analysis to Investigate Local Epidemiology.
Microorganisms
December 2024
Operative Research Unit of Laboratory, Fondazione Policlinico Universitario Campus Bio-Medico, Via Alvaro del Portillo, 200, 00128 Rome, Italy.
Multidrug-resistant is a significant healthcare challenge that particularly affects vulnerable patients through opportunistic nosocomial infections. Surveillance is crucial for monitoring the prevalence of these infections. Eighty-four KPC strains (2019-2022) were collected from patients admitted in Fondazione Policlinico Universitario Campus Bio-Medico.
View Article and Find Full Text PDFA Possible Tool for Guiding Therapeutic Approaches to Urinary Infections with : Analyzing a Dataset from a Romanian Tertiary Hospital.
Antibiotics (Basel)
December 2024
"Dr Victor Babes" Clinical Hospital of Infectious and Tropical Diseases, "Carol Davila" University of Medicine and Pharmacy, 030303 Bucharest, Romania.
The emergence of carbapenem-resistant pathogenic bacteria is a growing global public health concern. Carbapenem-resistant uropathogenic strains of can cause uncomplicated or complicated urinary tract infections, leading to a high risk of treatment failure and the spread of resistance determinants. The objectives of this 24-month study were to identify the prognostic characteristics of patients who were infected with carbapenem-resistant () and to create a tool to estimate the probability of a infection before having the complete results of a patient's antibiogram.
View Article and Find Full Text PDFEpidemiological Profile of Bacterial Infections in Burn Patients Over a Five-Year Period.
Cureus
November 2024
Bacteriology Laboratory, Faculty of Medicine and Pharmacy, Mohammed V Military Training Hospital, Mohammed V University, Rabat, MAR.
Introduction: Burn patients are highly susceptible to bacterial infections, which significantly increase morbidity and mortality. Destruction of skin barriers following burns creates an ideal environment for tissue colonization by pathogenic microorganisms.
Objectives: The aim of our study is to establish the epidemiological profile of bacterial infections in burn patients hospitalized in the Burns and Plastic Surgery Department of the Mohamed V Military Teaching Hospital (HMIMV) in Rabat and to describe their sensitivity to antibiotics.
Employing artificial intelligence for optimising antibiotic dosages in sepsis on intensive care unit: a study protocol for a prospective observational study (KI.SEP).
BMJ Open
December 2024
Klinik für Anästhesiologie, Intensivmedizin und Schmerztherapie, Universitätsklinikum Knappschaftskrankenhaus Bochum GmbH, Bochum, Germany
Introduction: In sepsis treatment, achieving and maintaining effective antibiotic therapy is crucial. However, optimal antibiotic dosing faces challenges due to significant variability among patients with sepsis. Therapeutic drug monitoring (TDM), the current gold standard, lacks initial dosage adjustments and global availability.
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