This study was designed to demonstrate a role of serotonin in the anticonvulsant effect of fluoxetine, a serotonin reuptake inhibitor, in genetically epilepsy-prone rats. When varied doses of 5-hydroxytryptophan (12.5, 25, 50 mg/kg) were administered i.p. along with a fixed dose of fluoxetine (15 mg/kg) to severe seizure genetically epilepsy-prone rats, the severity of audiogenic seizures was decreased dose-dependently, and the combination treatment also produced a marked potentiation of the anticonvulsant effect when compared with administration of either drug alone. Pretreatment of severe seizure genetically epilepsy-prone rats with p-chlorophenylalanine depleted brain serotonin and reduced the anticonvulsant effectiveness of fluoxetine. By using intracerebral microdialysis, the depletion of serotonin after p-chlorophenylalanine treatment was confirmed by measuring thalamic extracellular serotonin and 5-hydroxyindoleacetic acid concentrations during basal release and in response to a challenge dose of fluoxetine. We concluded that serotonergic transmission may be involved in the anticonvulsant effect of fluoxetine in severe seizure genetically epilepsy-prone rats.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/BF00241089 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Inhibition of TRPC3 channels suppresses seizure susceptibility in the genetically-epilepsy prone rats.
Eur J Pharmacol
August 2024
Department of Physiology and Biophysics, Howard University College of Medicine, Washington, DC, 20059, USA. Electronic address:
Transient receptor potential canonical 3 (TRPC3) channels are important in regulating Ca homeostasis and have been implicated in the pathophysiology of chemically induced seizures. Inherited seizure susceptibility in genetically epilepsy-prone rats (GEPR-3s) has been linked to increased voltage-gated Ca channel currents in the inferior colliculus neurons, which can affect intraneuronal Ca homeostasis. However, whether TRPC3 channels also contribute to inherited seizure susceptibility in GEPR-3s is unclear.
View Article and Find Full Text PDFInfluence of Inherited Seizure Susceptibility on Intermittent Voluntary Alcohol Consumption and Alcohol Withdrawal Seizures in Genetically Epilepsy-Prone Rats (GEPR-3s).
Brain Sci
February 2024
Department of Physiology and Biophysics, Howard University College of Medicine, Washington, DC 20059, USA.
Background: The link between epilepsy and alcohol consumption is complex, with conflicting reports. To enhance our understanding of this link, we conducted a study to determine how inherited seizure susceptibility affects voluntary alcohol consumption and influences alcohol withdrawal seizures in male and female genetically epilepsy-prone rats (GEPR-3s) compared to Sprague Dawley (SD) rats.
Methods: In the first experiment, animals were given access to two bottles simultaneously, one containing water and the other 7.
Aberrant survival of hippocampal Cajal-Retzius cells leads to memory deficits, gamma rhythmopathies and susceptibility to seizures in adult mice.
Nat Commun
March 2023
Université Paris Cité, Imagine Institute, Team Genetics and Development of the Cerebral Cortex, 75015, Paris, France.
Cajal-Retzius cells (CRs) are transient neurons, disappearing almost completely in the postnatal neocortex by programmed cell death (PCD), with a percentage surviving up to adulthood in the hippocampus. Here, we evaluate CR's role in the establishment of adult neuronal and cognitive function using a mouse model preventing Bax-dependent PCD. CRs abnormal survival resulted in impairment of hippocampus-dependent memory, associated in vivo with attenuated theta oscillations and enhanced gamma activity in the dorsal CA1.
View Article and Find Full Text PDFCannabidiol attenuates generalized tonic-clonic and suppresses limbic seizures in the genetically epilepsy-prone rats (GEPR-3) strain.
Pharmacol Rep
February 2023
Department of Pharmacology and Physiology, Georgetown University, New Research Bldg., W209B, 3970 Reservoir Road NW, Washington, DC, 20007, USA.
Article Synopsis
- Cannabidiol (CBD) shows potential as an effective treatment for epilepsy, particularly in genetically predisposed rats that exhibit two types of seizures: generalized tonic-clonic and limbic seizures.
- In the study, CBD was tested at various doses (1, 10, 50, and 100 mg/kg) and was found to significantly reduce the severity and duration of generalized tonic-clonic seizures, especially at higher doses.
- Additionally, CBD at a lower dose of 10 mg/kg was able to lessen the severity of limbic seizures in a majority of the tested rats, indicating its promise as a pharmacological option for treating different seizure types.
Liraglutide chronic treatment prevents development of tolerance to antiseizure effects of diazepam in genetically epilepsy prone rats.
Eur J Pharmacol
August 2022
System and Applied Pharmacology@University Magna Grecia, Science of Health Department, School of Medicine, Magna Graecia University of Catanzaro, Catanzaro, Italy.
Glucagon-like peptide-1 (GLP-1) is a hormone that can regulate several neuronal functions. The modulation of GLP-1 receptors emerged as a potential target to treat several neurological diseases, such as epilepsy. Here, we studied the effects of acute and chronic treatment with liraglutide (LIRA), in genetically epilepsy prone rats (GEPR-9s).
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!