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Article Synopsis
- * The disease is complex and involves immune responses where CD8+ T-cells target melanocytes, and various treatment strategies include phototherapy, grafting, and new drugs like JAK-STAT inhibitors.
- * Future research should focus on exploring alternative drug targets, genetic factors, and immune cell treatments, potentially leading to more effective and lasting solutions for vitiligo.
Efficacy of Pseudo-Ceramide Absorption Into the Stratum Corneum and Effects on Transepidermal Water Loss and the Ceramide Profile: A Randomized Controlled Trial.
J Cosmet Dermatol
January 2025
Skin Care Products Research Laboratory, Kao Corporation, Odawara, Kanagawa, Japan.
Background: Changes in the level or profile of ceramides are associated with decreased stratum corneum (SC) barrier function. Topical application of a pseudo-ceramide (pCer)-containing moisturizer can improve barrier function. Additionally, pCer that absorbs into the SC may improve ceramide profiles.
View Article and Find Full Text PDFLaser-Induced Koebner-Related Skin Reactions: A Clinical Overview.
Medicina (Kaunas)
July 2024
Department of Dermatology, Faculty of Medicine, School of Health Sciences, University General Hospital of Larissa, University of Thessaly, 41110 Larissa, Greece.
The Koebner phenomenon (KP), also known as the isomorphic response, describes the process by which new lesions that are clinically and histologically identical to a patient's existing skin disease develop following trauma. Many skin diseases exhibit this characteristic, with variations that include possible, questionable, and pseudo-Koebner reactions, with the latter category occurring due to infectious agents seeding at a trauma site. Laser application, a type of controlled skin injury used for improving cutaneous lesions and skin rejuvenation, is also considered a form of trauma.
View Article and Find Full Text PDFLeukomelanoderma Resembling Hyperpigmented Mycosis Fungoides.
Acta Dermatovenerol Croat
March 2024
Kozo Nakai, MD, PhD, Professor and Chairman, Department of Dermatology, Kochi Medical School, Kochi University, Kohasu, Oko-cho, Nankoku, Kochi 783-8505, Japan;
Acquired circumscribed hyperpigmented patches and plaques have various differential diagnoses, including post-inflammatory hyperpigmentation and mycosis fungoides (MF). Leukomelanoderma is an uncommon cutaneous condition in which the pathogenesis is not fully elucidated. It has been reported that leukomelanoderma occurs after allergic contact dermatitis from hydroquinone or acute cutaneous graft-versus-host disease (1,2).
View Article and Find Full Text PDFORF virus causes tumor-promoting inflammation in sheep and goats.
Vet Pathol
September 2024
Istituto Zooprofilattico Sperimentale della Sardegna, Sassari, Italy.
Article Synopsis
- ORF virus (ORFV) causes contagious ecthyma in sheep and goats, leading to various skin lesions, prompting a study into the molecular factors behind these atypical tumor-like changes.
- The research involved 15 lambs and 15 kids, revealing ORFV in their lesioned tissues and surprisingly in healthy goats from the same herd, indicating the virus's prevalence.
- Key findings showed significant growth factor expression, particularly vVEGF and VEGFR2, associated with CD163+ macrophages, suggesting an inflammatory response potentially linked to oncogenic processes due to their interactions.
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