A histological and ultrastructural study of dense foci characteristics for soft tissues in fibromyalgia syndrome revealed that they consist of rough fibrillar connective tissue frequently hyalinized. Vascularization occurred at the periphery of these foci only where thin nervous fibrils and sometimes small paraganglia were seen. Severe degenerative changes of the collagen fibers, marked decrease and degeneration of fibroblasts were found electron microscopically. Signs of inflammation were absent.

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