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A pan-cancer analysis of thioredoxin-interacting protein as an immunological and prognostic biomarker.
Cancer Cell Int
July 2022
Guangdong Provincial Key Laboratory of Gastroenterology, Department of Gastroenterology, Nanfang Hospital, Southern Medical University, No. 1838, Guangzhou Avenue North, Guangzhou, 510515, Guangdong, People's Republic of China.
Background: The critical role of thioredoxin-interacting protein (TXNIP) in cellular sulfhydryl redox homeostasis and inflammasome activation is already widely known, however, no pan-cancer analysis is currently available.
Methods: We thus first explored the potential roles of TXNIP across thirty-three tumors mainly based on The Cancer Genome Atlas and Gene Expression Omnibus datasets.
Results: TXNIP is lowly expressed in most cancers, and distinct associations exist between TXNIP expression and the prognosis of tumor patients.
WW Domain-Containing E3 Ubiquitin Protein Ligase 1: A Self-Disciplined Oncoprotein.
Front Cell Dev Biol
October 2021
Department of Laboratory Medicine, West China Second University Hospital, Sichuan University, Chengdu, China.
WW domain-containing E3 ubiquitin protein ligase 1 (WWP1) is a member of C2-WW-HECT E3 ligase family. Although it may execute carcinostatic actions in some scenarios, WWP1 functions as an oncoprotein under most circumstances. Here, we comprehensively review reports on regulation of WWP1 and its roles in tumorigenesis.
View Article and Find Full Text PDFNatural products based crown ethers: synthesis and their anticancer potential.
J Asian Nat Prod Res
March 2022
H.E.J. Research Institute of Chemistry, ICCBS, University of Karachi, Karachi 75270, Pakistan.
Natural products based novel crown ethers have been prepared by employing biologically active natural structures including tetrahydroisoquinoline, chrysin and biochanin-A as the side arms. The resulting crown scaffolds were evaluated for their anticancer potential against two cancer cell lines i.e.
View Article and Find Full Text PDFSCD5 expression correlates with prognosis and response to neoadjuvant chemotherapy in breast cancer.
Sci Rep
April 2021
Department of Breast Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, People's Republic of China.
Neoadjuvant chemotherapy (NACT) represents a standard option for breast cancer. Unfortunately, about 55-80% of breast cancer patients do not have a favorable response to chemotherapy. Highly specific tumor biomarker that can predict the pathological response to neoadjuvant chemotherapy is lacking.
View Article and Find Full Text PDFDevelopment and validation of DGT passive samplers for the quantification of Ir, Pd, Pt, Rh and Ru: A challenging application in waters impacted by urban activities.
Talanta
February 2021
Univ. Lille, CNRS, UMR 8516 - LASIRE - LAboratoire de Spectroscopie pour Les Interactions, La Réactivité et L'Environnement, F-59000, Lille, France.
Platinum group elements (PGEs) are among the least abundant in the continental crust. They have become excellent tracers of anthropogenic activities, particularly due to their use in catalytic converters or in the medical industry. However, their quantification in environmental matrices is still problematic because of their low concentrations combined with the presence of interfering elements.
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