Molecular and clinical aspects of HIV-1 pathogenesis are described, including the turnover of the HIV-1 population in vivo, the clinical significance of resistance to HIV-1 reverse transcriptase (RT) inhibitors, and the inter-relationship between virus replication and RT inhibitor resistance. The molecular genetics of RT inhibitor resistance, including interactive effects of different RT mutations and the implications of those effects for combination chemotherapy, are summarized. Structural studies of RT and the biochemical bases of drug resistance are discussed.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
drug resistance
8
resistance molecular
8
inhibitor resistance
8
resistance
5
hiv-1
4
hiv-1 drug
4
molecular pathogenesis
4
pathogenesis laboratory
4
laboratory monitoring
4
monitoring molecular
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!