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miRNA506 Activates Sphk1 Binding with Sirt1 to Inhibit Brain Injury After Intracerebral Hemorrhage via PI3K/AKT Signaling Pathway.
Mol Neurobiol
October 2024
Emergency and Critical Care Center, Intensive Care Unit, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, 310014, Zhejiang, China.
Article Synopsis
- Intracerebral hemorrhage (ICH) causes high rates of mortality and disability, with 75% of survivors suffering neurological deficits.
- The study utilized in vivo rat models and in vitro neuronal models to investigate the role of Sphk1 in reducing inflammation and cell death associated with ICH.
- Findings suggest that increasing Sphk1 expression helps protect against neurological damage by modulating inflammation and enhancing survival of brain cells, indicating potential therapeutic targets for ICH treatment.
Atomoxetine on neurogenic orthostatic hypotension: a randomized, double-blind, placebo-controlled crossover trial.
Clin Auton Res
December 2024
Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University Medical Center, 506 Robinson Research Building, Nashville, TN, 37232-8802, USA.
Article Synopsis
Does Neuromuscular Training Reduce the Risk of Lower-Extremity Musculoskeletal Injury in High School Female Athletes With a History of Sport-Related Concussion?
J Sport Rehabil
September 2024
Emory Sports Performance and Research Center (SPARC), Emory University, Flowery Branch, GA, USA.
Context: There is a well-established increased risk of lower-extremity (LE) musculoskeletal (MSK) injury following a sport-related concussion (SRC). Neuromuscular training programs improve biomechanics associated with LE MSK injury and reduce LE MSK injury incidence, but their relative effectiveness in athletes with history of SRC is unknown. The purpose of this study was to evaluate LE MSK injury incidence in female adolescent athletes with history of SRC following a neuromuscular training intervention.
View Article and Find Full Text PDFOleanolic acid-3-glucoside, a synthetic oleanane-type saponin, ameliorates methylmercury-induced dysfunction of synaptic transmission in mice.
Toxicology
August 2024
School of Pharmacy, Kitasato University, 5-9-1, Shirokane, Minato-ku, Tokyo 108-8641, Japan. Electronic address:
Methylmercury (MeHg) is widely distributed in nature and is known to cause neurotoxic effects. This study aimed to examine the anti-MeHg activity of oleanolic acid-3-glucoside (OA3Glu), a synthetic oleanane-type saponin derivative, by evaluating its effects on motor function, pathology, and electrophysiological properties in a mouse model of MeHg poisoning. Mice were orally administered 2 or 4 mg·kg·d MeHg with or without 100 µg·kg·d OA3Glu 5x/week for four weeks.
View Article and Find Full Text PDFMalnutrition in Head and Neck Free Flap Reconstruction as a Predictor of Adverse Outcomes.
Ann Plast Surg
April 2024
From the Division of Plastic Surgery, Department of Surgery, Rutgers New Jersey Medical School, Newark, NJ.
Introduction: Malnutrition is associated with increased mortality in patients with head and neck (H&N) cancer. Because albumin levels are used as a surrogate for nutritional status, the purpose of this study is to assess whether malnutrition is associated with adverse postoperative outcomes in H&N free flap reconstruction.
Materials And Methods: The 2006-2018 National Surgical Quality Improvement Program Database was queried for patients undergoing flap procedures of the H&N based on Current Procedure Terminology codes.
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