Distribution of the HLA system Class 1 specificities was studied in 97 patients with thyroid carcinoma, 101 ones with nodular goiter and 500 donors in the Central Urals. B15, B18 antigens were very frequent and All antigens quite rare in the patients with thyroid carcinoma; in patients with nodular goiter the incidence of Aw19, A28, B18 antigens was the highest, whereas the incidence of A11 antigen and the A2-B35 haplotype was low. The groups of patients with thyroid carcinoma and nodular goiter differed only by the incidence of A28 antigen and A2-B35 haplotype, this fact indicating the immunogenetic similarity of the diseases in question. Similar pathogenetic mechanisms of the formation of mammary carcinoma and of nodular goiter in the thyroid may be supposed, this giving grounds for the radical approach to the treatment of nodular formations of the thyroid.
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