AI Article Synopsis
- Review of myelin basic protein (MBP) concentrations in cerebrospinal fluid (CSF) was conducted in 20 pediatric hydrocephalic patients, showing elevated levels, especially in children over 1 year old.
- After shunt placement, MBP concentrations significantly decreased, indicating it could serve as a marker for shunt effectiveness.
- Monitoring MBP levels in lumbar CSF may help determine the need for shunt surgery in cases of posthemorrhagic neonatal hydrocephalus.
Article Abstract
Concentrations of myelin basic protein (MBP) in ventricular and lumbar cerebrospinal fluid (CSF) of 20 pediatric hydrocephalic patients were reviewed. Raised values were found to be particularly significant in children aged more than 1 year. Control measurements after shunt placement showed an important drop in the MBP concentration, which could therefore be considered a marker for correct functioning of the shunt. The dosage of MBP could play a role in assessing the activity of an hydrocephalic process. Preliminary data gained from monitoring of MBP in the lumbar CSF in posthemorrhagic neonatal hydrocephalus could yield further criteria for indication of a shunt operation.
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| http://dx.doi.org/10.1007/BF00302771 | DOI Listing |
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