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Short-term Patient-Reported Outcomes Following Bilateral Risk-Reducing Mastectomy for Patients at a High Risk for Breast Cancer: A Systematic Review.
Ann Surg Oncol
January 2025
Department of Surgery, Duke University Medical Center, Durham, NC, USA.
Background: Bilateral risk-reducing mastectomies (RRMs) have been proven to decrease the risk of breast cancer in patients at high risk owing to family history or having pathogenic genetic mutations. However, few resources with consolidated data have detailed the patient experience following surgery. This systematic review features patient-reported outcomes for patients with no breast cancer history in the year after their bilateral RRM.
View Article and Find Full Text PDFContamination assessment and source identification of metals and metalloids in submicron road dust (PM) in Moscow Megacity.
Environ Sci Pollut Res Int
January 2025
Faculty of Geography, Lomonosov Moscow State University, 119991, Moscow, Russia.
The content of 39 metals and metalloids (MMs) in submicron road dust (PM fraction) was studied in the traffic zone, residential courtyards with parking lots, and on pedestrian roads in parks in Moscow. The geochemical profiles of PM vary slightly between different types of roads and courtyards but differ significantly from those in parks. In Moscow, compared to other cities worldwide, submicron road dust contains less As, Sb, Mo, Cr, Cd, Sn, Tl, Ca, Rb, La, Y, U, but more Cu, Zn, Co, Fe, Mn, Ti, Zr, Al, V.
View Article and Find Full Text PDFA 3D Computational Study on the Formation and Progression of Tumor Cells in Diffuse Gastric Cancer.
Bull Math Biol
January 2025
CFisUC, Department of Physics, University of Coimbra, Rua Larga, 3004-516, Coimbra, Portugal.
Hereditary diffuse gastric cancer is characterized by an increased risk of diffuse gastric cancer and lobular breast cancer, and is caused by pathogenic germline variants of E-cadherin and -E-catenin, which are key regulators of cell-cell adhesion. However, how the loss of cell-cell adhesion promotes cell dissemination remains to be fully understood. Therefore, a three-dimensional computer model was developed to describe the initial steps of diffuse gastric cancer development.
View Article and Find Full Text PDFUnveiling the potential of spirulina algal extract as promising antibacterial and antibiofilm agent against carbapenem-resistant Klebsiella pneumoniae: in vitro and in vivo study.
Microb Cell Fact
January 2025
Pharmaceutical Microbiology Department, Faculty of Pharmacy, Tanta University, Tanta, 31527, Egypt.
Carbapenem-resistant Klebsiella pneumoniae poses a severe risk to global public health, necessitating the immediate development of novel therapeutic strategies. The current study aimed to investigate the effectiveness of the green algae Arthrospira maxima (commercially known as Spirulina) both in vitro and in vivo against carbapenem-resistant K. pneumoniae.
View Article and Find Full Text PDFPerioperative outcomes in an age-adapted analysis of the German StuDoQ|Pancreas registry for PDAC.
BMC Surg
January 2025
Department of General, Visceral and Transplantation Surgery, LMU University Hospital Munich, LMU Munich, Munich, Germany.
Background: Pancreatic ductal adenocarcinoma (PDAC) typically occurs in an older patient population. Yet, early-onset pancreatic cancer (EOPC) has one of the fastest growing incidence rates. This study investigated the influence of age and tumor location on postoperative morbidity and mortality in a large, real-world dataset.
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