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Primary clear cell sarcoma of the femur: a unique case with RT-PCR and direct sequencing confirmation of EWSR1/ATF1 fusion gene.
BMC Musculoskelet Disord
January 2021
Department of Orthopaedic Surgery, Faculty of Medicine, Oita University, 1-1 Idaigaoka Hasama, 879-5593, Yufu City, Oita, Japan.
Background: It is very rare for clear cell sarcomas (CCS) to arise in the bone. During diagnosis, it is important to distinguish primary CCS of bone from bone metastasis of melanoma because this difference fundamentally changes the therapeutic options. Recently, characteristic fusion genes of CCS have been detected using reverse transcription polymerase chain reaction (RT-PCR) or direct sequencing which allowed to distinguish CCS from melanoma.
View Article and Find Full Text PDFThe new AJCC guidelines in practice: utility of the MITF immunohistochemical stain in the evaluation of single-cell metastasis in melanoma sentinel lymph nodes.
Am J Surg Pathol
June 2013
Department of Pathology, Loyola University Medical Center, Maywood, IL 60153, USA.
The American Joint Commission on Cancer 2010 guideline changes recommend all patients with single-cell melanoma metastasis identified by immunhistochemical staining of sentinel lymph nodes to be classified as N1 stage. In this study we evaluated the utility of adding microphthalmia transcription factor (MITF) to our current sentinel node evaluation protocol. Twenty benign lymph nodes from nonmelanoma patients were stained with MITF, MART-1/Melan-A, and HMB-45.
View Article and Find Full Text PDFThe use of immunocytochemical study in the cytologic diagnosis of melanoma: evaluation of three antibodies.
Diagn Cytopathol
February 2013
Department of Pathology, University of Michigan Hospital System, Ann Arbor, Michigan 48109-0054, USA.
There are limited studies on the utility of immunostaining in cytologic specimens suspected of melanoma. In this study, we examined the performance of the most commonly used antibodies including monoclonal antibodies against Melan-A (A103), S-100, and HMB-45 antigens. Immunostains were performed on formalin-fixed, paraffin-embedded cell blocks prepared from 100 cytologic specimens.
View Article and Find Full Text PDFFine needle aspiration biopsy with liquid-based cytology and adjunct immunohistochemistry in intraocular melanocytic tumors.
Eur J Ophthalmol
December 2010
Department of Ophthalmology, LIOCiV (Laboratory of Ophthalmic Research and Visual Sciences), School of Medicine, Buenos Aires University, Buenos Aires, Argentina.
Purpose: To determine the efficacy of liquid-based cytology (LBC) and immunohistochemistry in the evaluation of fine needle aspiration biopsy (FNAB) of intraocular melanocytic tumors.
Methods: Cytologic diagnosis was necessary in 25 patients with intraocular melanocytic tumors to deliver a therapeutic course of treatment. The patients' clinical, cytologic, and histologic diagnoses were correlated.
Intraoperative evaluation of sentinel lymph nodes for metastatic melanoma by imprint cytology.
Ann Surg Oncol
May 2007
Surgical Oncology Service and Department of Surgery, Wake Forest University School of Medicine, Medical Center Blvd, Winston-Salem, North Carolina 27157, USA.
Background: Sentinel lymph node biopsy (SLN) has revolutionized nodal staging. Accurate intraoperative evaluation of SLN permits a single procedure, with lymphadenectomy being performed during the initial operative procedure when the SLN is positive. There is a paucity of literature on intraoperative imprint cytology (IIC) evaluation of the SLN in melanoma.
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