Mapping of the genetic defect causing dominant palmoplantaris hyperkeratosis (PPHK) was continued based on the material of an extended Uzbek pedigree. No linkage between the PPHK gene and hypervariable DNA markers from 8p, 12p, 14q, and 22q were revealed. The study of PPHK gene linkage with DNA markers covering the entire length of 17th chromosome mapped the PPHK gene to 17q12-q24 and revealed close linkage with KRT10 and D17S800 loci (zero recombination frequency at a lod score > 7). The possible location of a PPHK mutation in one of the keratin genes mapped to the same region on the 17th chromosome is discussed.

Download full-text PDF

Source

Publication Analysis

Top Keywords

pphk gene
12
dna markers
8
17th chromosome
8
pphk
5
[mapping gene
4
gene palmoplantar
4
palmoplantar hyperkeratosis
4
hyperkeratosis thylosis
4
thylosis chromosome
4
chromosome 17q12-q24
4

Similar Publications

Postharvest nitric oxide treatment induced the alternative oxidase pathway to enhance antioxidant capacity and chilling tolerance in peach fruit.

Plant Physiol Biochem

October 2021

Key Laboratory of Agro-products Quality and Safety Control in Storage and Transport Process, Ministry of Agriculture and Rural Affairs/ Institute of Food Science and Technology, Chinese Academy of Agricultural Sciences, Beijing, 100193, People's Republic of China. Electronic address:

Nitric oxide (NO) is an important regulator of plant response to cold stress. In this study, NO treatment delayed the development of chilling injury (CI), inhibited the increase in HO content, O production rate and decrease in firmness of postharvest peach fruit. Meanwhile, through RNA-seq analysis, NO treatment up-regulated gene expression of PpG-6-PDH, Pp6-PGDH and PpAOX while it down-regulated the expression of PpGPI and PpHK, suggesting that the pentose phosphate respiratory pathway and cyanide-resistant respiratory pathway were promoted and the glycolysis pathway was inhibited.

View Article and Find Full Text PDF

Mapping of the genetic defect causing dominant palmoplantaris hyperkeratosis (PPHK) was continued based on the material of an extended Uzbek pedigree. No linkage between the PPHK gene and hypervariable DNA markers from 8p, 12p, 14q, and 22q were revealed. The study of PPHK gene linkage with DNA markers covering the entire length of 17th chromosome mapped the PPHK gene to 17q12-q24 and revealed close linkage with KRT10 and D17S800 loci (zero recombination frequency at a lod score > 7).

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!