Cranial bone grafts play a steadily increasing role as the dominant material used for reconstruction of defects within the frontal region. Both clinical experience and experiments on animals provided evidence that they showed a much smaller degree of resorption and that their cutting was associated with a markedly lower frequency of complications. Cranial bone grafts were used for the reconstruction of frontal defects in 17 patients. The results assessed six years after surgery disclosed a very slight degree of resorption in the presence of very good functional and cosmetic effects.
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Blood
January 2025
Division of Immunology and Allergy, Children's Hospital of Philadelphia; Department of Pediatrics, Perelman School of Medicine; Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States.
Leukopoiesis is lethally arrested in mice lacking the master transcriptional regulator PU.1. Depending on the animal model, subtotal PU.
View Article and Find Full Text PDFJBJS Case Connect
January 2025
Department of Orthopedic Surgery, Shariati Hospital and School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Case: In this article, we present 2 cases of neglected patellar tendon rupture. One was treated using an Achilles tendon allograft, and the other with a patellar tendon-bone allograft. Both methods allowed for early range of motion and resulted in good functional outcomes with a 1-year follow-up period.
View Article and Find Full Text PDFPLoS One
January 2025
Department of Surgical Pathology, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Immunologic bile duct destruction is a pathogenic condition associated with vanishing bile duct syndrome (VBDS) after liver transplantation and hematopoietic stem-cell transplantation. As the bile acid receptor sphingosine 1-phosphate receptor 2 (S1PR2) plays a critical role in recruitment of bone marrow-derived monocytes/macrophages to sites of cholestatic liver injury, S1PR2 expression was examined using cultured macrophages and patient tissues. Bile canaliculi destruction precedes intrahepatic ductopenia; therefore, we focused on hepatocyte S1PR2 and the downstream RhoA/Rho kinase 1 (ROCK1) signaling pathway and bile canaliculi alterations using three-dimensional hepatocyte culture models that form obvious bile canaliculus-like networks.
View Article and Find Full Text PDFEur J Trauma Emerg Surg
January 2025
Department of Hand and Upper Extremity Surgery, Edouard Herriot Hospital, 5 place d'Arsonval, Lyon, 69003, France.
Purpose: To report the radiological outcomes and complications of the Masquelet induced membrane technique (IMT) for acute bone reconstruction in complex hand injuries.
Methods: We retrospectively reviewed 22 patients treated primarily by the IMT for bone defect of the phalanx and/or metacarpals bones in 26 injured digits. The median bone defect length was 17 mm (IQR 13-25).
Facial Plast Surg Aesthet Med
January 2025
Division of Otolaryngology-Head & Neck Surgery, Department of Surgery, Health Sciences Center, University of New Mexico, Albuquerque, New Mexico, USA.
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