AI Article Synopsis
- A study found elevated levels of myelin basic protein (MBP) in the ventricular cerebrospinal fluid (CSF) of 17 hydrocephalic patients who had shunts.
- Analysis of CSF samples from both the ventricle and lumbar region revealed a strong concentration ratio of 20:1.
- Following shunt surgery, the elevated MBP levels in ventricular CSF significantly dropped, indicating that MBP could be a useful indicator of brain damage in hydrocephalus and might help in deciding the need for shunt operations.
Article Abstract
Raised ventricular CSF myelin basic protein (MBP) concentration has been evidenced in 17 shunted hydrocephalic patients. Contemporary evaluation both from ventricular and lumbar CSF samples showed a concentration ratio of 20:1. In all cases the raised values of ventricular CSF concentration of MBP demonstrated a significant decrease after shunt operation. This preliminary report suggests that this marker is an important index of actual brain damage in hydrocephalus and could be taken in account for the indication of shunt operation.
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