A total of 40 patients with various ocular diseases were treated with nimesulide 200 mg/day or ketoprofen 150 mg/day for 7 days after laser therapy. The incidence of ocular complications was lower in patients treated with nimesulide than with ketoprofen. With regard to posterior segment changes, retinal oedema was reduced in patients treated with nimesulide. After laser treatment, anterior segment changes were modest. These preliminary results stress the efficacy of nimesulide in preventing oedema and also its anti-inflammatory effects on the retina after ocular laser therapy.
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http://dx.doi.org/10.2165/00003495-199300461-00044 | DOI Listing |
Zh Nevrol Psikhiatr Im S S Korsakova
December 2024
Clinical Hospital of St. Luka, St. Petersburg, Russia.
Objective: To analyze the efficacy and tolerability of aceclofenac in the treatment of patients with acute non-specific musculoskeletal pain in the lower back (ANBP) compared with other NSAIDs (dexketoprofen, nimesulide and lornoxicam), as well as to assess the impact of NSAIDs therapy on the relative risk of recurrence and chronicity of this pathology.
Material And Methods: The study involved 80 patients (47 women and 33 men), average age 52.6 [47.
Mol Divers
September 2024
MIT ADTU School of Bioengineering Sciences & Research, MIT Art, Design and Technology University, Pune, Maharashtra, India.
Gastric cancer poses a significant global health challenge, necessitating innovative approaches for biomarker discovery and therapeutic intervention. This study employs a multifaceted strategy integrating network biology, drug repurposing, and virtual screening to elucidate and expand the molecular landscape of gastric cancer. We identified and prioritized key genes implicated in gastric cancer by utilizing data from diverse databases and text-mining techniques.
View Article and Find Full Text PDFFront Pharmacol
September 2024
Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and the Ministry of Education of China, Guangzhou Medical University, Guangzhou, China.
Background And Aim: Non-steroidal anti-inflammatory drugs (NSAIDs) are commonly used to treat fever, pain, and inflammation. Concerns regarding their cardiovascular safety have been raised. However, the underlying mechanism behind these events remains unknown.
View Article and Find Full Text PDFMaterials (Basel)
August 2024
Medical College, University of Rzeszow, 1a Warzywna Street, 35-310 Rzeszow, Poland.
One of the intensively developed tools for cancer therapy is drug-releasing matrices. Polyamidoamine dendrimers (PAMAM) are commonly used as nanoparticles to increase the solubility, stability and retention of drugs in the human body. Most often, drugs are encapsulated in PAMAM cavities or covalently attached to their surface.
View Article and Find Full Text PDFHeliyon
August 2024
College of Medical Informatics, Chongqing Medical University, Chongqing, 400016, China.
Background: Osteoarthritis (OA) is the most common form of joint diseases, with hallmark of cartilage degeneration. Recent studies have shown that the pathogenesis of OA is associated with chondrocyte necroptosis.
Methods: In this study, we used single-cell RNA sequencing (scRNA-seq) and bulk RNA sequencing data to analyze necroptosis regulation in OA chondrocytes.
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