AI Article Synopsis
- Endothelial cell stimulating angiogenesis factor (ESAF) plays a crucial role in the formation of new blood vessels needed for bone growth, particularly in conditions like healing fractures and osteoarthritis.
- A study involving 41 ankylosing spondylitis (AS) patients showed that their ESAF levels were significantly higher compared to age-matched controls.
- Interestingly, within the AS group, patients with higher ESAF levels did not exhibit any distinct clinical or radiological features.
Article Abstract
Endothelial cell stimulating angiogenesis factor (ESAF) is important in the neovascularisation that precedes new bone formation, and raised levels are found in association with healing fractures and osteoarthritis. We investigated its relevance to the new bone growth that is found at inflammatory sites in ankylosing spondylitis (AS). Forty-one patients with AS were studied clinically and radiographically and had their serum ESAF levels measured. In comparison to age-matched controls the AS patients had significantly raised ESAF levels (p < 0.0001). Within the AS group, patients with relatively higher ESAF levels had no characteristic clinical or radiological features.
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